术前膳食抗氧化指数与食管鳞癌患者术后生活质量的关系：基于 TTD 模型的前瞻性研究。

Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model.

机构信息

Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Department of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China.

出版信息

Nutrients. 2023 Jun 21;15(13):2828. doi: 10.3390/nu15132828.

DOI:10.3390/nu15132828

PMID:37447155

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10343810/

Abstract

OBJECTIVE

Dietary antioxidants are associated with risk of death in cancer patients, and they were used to evaluate the prognosis of cancer patients. Dietary antioxidant index (DAI) can be used to evaluate dietary antioxidant content comprehensively; this study aimed to investigate the effect of preoperative DAI on health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC).

METHODS

Data on dietary intakes were collected using a validated food-frequency questionnaire (FFQ). DAI was calculated for all study participants based on FFQ data of each participant. The study involved conducting several follow-up activities with patients diagnosed with ESCC to evaluate their quality of life. The approach employed in the study was to conduct a telephone interview. The EORTC Quality of Life Questionnaire-Core Questionnaire (EORTC QLQ-C30, version 3.0) and the Esophageal Cancer Module (EORTC QLQ-OES18) were used to collect data on the quality of life of the patients; all patients completed the full follow-up.

RESULTS

This prospective study was performed on 376 participants who were recruited from Fujian Cancer Hospital and First Hospital of Fujian Medical University. They all were diagnosed with ESCC. The results indicated that the time to deterioration of global health status ( = 0.043), cognitive functioning ( = 0.031), dry mouth ( = 0.019), and speech problems ( = 0.031) significantly delay in the high DAI group. Univariate and multivariate Cox regression analysis showed that global health status ( = 0.718, : 0.532-0.969), cognitive functioning ( = 0.641, : 0.450-0.913), dry mouth ( = 0.637, : 0.445-0.911), and speech problems ( = 0.651, : 0.449-0.945) were improved in the high DAI group.

CONCLUSIONS

Prognostic value of preoperative DAI was significant for patients with ESCC who undergo surgical intervention. Its level was positively correlated with the postoperative quality of life of patients, which can delay and improve the occurrence of postoperative physical function and symptom deterioration.

摘要

目的

饮食中的抗氧化剂与癌症患者的死亡风险相关，因此被用于评估癌症患者的预后。饮食抗氧化指数（DAI）可用于全面评估饮食中的抗氧化剂含量；本研究旨在探讨术前 DAI 对食管鳞癌（ESCC）患者健康相关生活质量的影响。

方法

采用经过验证的食物频率问卷（FFQ）收集饮食摄入量数据。根据每位参与者的 FFQ 数据计算所有研究参与者的 DAI。该研究对诊断为 ESCC 的患者进行了多次随访活动，以评估他们的生活质量。研究采用电话访谈的方式进行。使用欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30，版本 3.0）和食管癌模块（EORTC QLQ-OES18）收集患者的生活质量数据；所有患者均完成了完整的随访。

结果

这项前瞻性研究共纳入 376 名来自福建省肿瘤医院和福建医科大学第一附属医院的 ESCC 患者。结果表明，在高 DAI 组中，全球健康状况恶化的时间（ = 0.043）、认知功能（ = 0.031）、口干（ = 0.019）和言语问题（ = 0.031）显著延迟。单变量和多变量 Cox 回归分析显示，全球健康状况（ = 0.718，95%CI：0.532-0.969）、认知功能（ = 0.641，95%CI：0.450-0.913）、口干（ = 0.637，95%CI：0.445-0.911）和言语问题（ = 0.651，95%CI：0.449-0.945）在高 DAI 组中得到改善。