College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Department of Food Sciences and Technology, Faculty of Agriculture and Food Sciences, Ibb University, Ibb 70270, Yemen.
Nutrients. 2023 Jun 27;15(13):2923. doi: 10.3390/nu15132923.
This study evaluated the cholesterol-alleviating effect and underlying mechanisms of chitosan-oligosaccharide (COS) in hypercholesterolemic hamsters. Male hamsters ( = 24) were divided into three groups in a random fashion, and each group was fed one particular diet, namely a non-cholesterol diet (NCD), a high-cholesterol diet (HCD), and an HCD diet substituting 5% of the COS diet for six weeks. Subsequently, alterations in fecal bile acids (BAs), short-chain fatty acids (SCFAs), and gut microflora (GM) were investigated. COS intervention significantly reduced and increased the plasma total cholesterol (TC) and high-density lipoprotein-cholesterol (HDL-C) levels in hypercholesteremic hamsters. Furthermore, Non-HDL-C and total triacylglycerols (TG) levels were also reduced by COS supplementation. Additionally, COS could reduce and increase food intake and fecal SCFAs (acetate), respectively. Moreover, COS had beneficial effects on levels of BAs and GM related to cholesterol metabolism. This study provides novel evidence for the cholesterol-lowering activity of COS.
本研究评估了壳寡糖（COS）在高胆固醇血症仓鼠体内的降胆固醇作用及其潜在机制。雄性仓鼠（n=24）随机分为三组，每组分别喂食一种特定的饮食，即无胆固醇饮食（NCD）、高胆固醇饮食（HCD）和用 5%的 COS 饮食替代 HCD 饮食喂养六周。随后，研究了粪便胆汁酸（BAs）、短链脂肪酸（SCFAs）和肠道微生物群（GM）的变化。COS 干预显著降低和升高了高胆固醇血症仓鼠的血浆总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）水平。此外，COS 补充还降低了非高密度脂蛋白胆固醇和总三酰甘油（TG）水平。此外，COS 分别减少和增加了食物摄入和粪便 SCFAs（乙酸盐）。此外，COS 对与胆固醇代谢相关的 BAs 和 GM 水平有有益的影响。本研究为 COS 的降胆固醇活性提供了新的证据。
