Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Metabolic Liver Disease Research Program, I. Department of Medicine, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Nutrients. 2023 Jul 2;15(13):3018. doi: 10.3390/nu15133018.
Patients with non-alcoholic fatty liver disease (NAFLD) display impaired health-related quality of life (HRQoL) that is often linked to an unhealthy dietary pattern. The aim of this work was to investigate the impact of HRQoL and adherence to the Mediterranean diet on the risk of liver fibrosis (LF) in patients with NAFLD. LF was assessed in 244 patients through transient elastography (FibroScan530. Echosens, Paris, France). Significant LF was defined according to liver stiffness measurements (LSM) values ≥ 7.1 kPa. The Mediterranean diet score and the Short Form-36 questionnaires were also completed. The median age was 54 (44-62) years and 57% of participants were male. A total of 42 (17.2%) participants had LSM ≥ 7.1 kPa and showed increased GGT ( = 0.001), glucose ( < 0.001), and triglycerides levels ( = 0.015) compared to those with LSM ≤7.0 kPa. Moreover, patients with significant LF had significantly lower scores related to Physical Functioning ( < 0.001) and Role Physical ( < 0.001). In the logistic regression analysis, lower role physical and lower adherence to the MedDiet ( = 0.001 and = 0.009, respectively), after adjusting for age, diabetes, and obstructive sleep apnea, were associated with an increased risk of significant LF. Low adherence to MedDiet and low role physical may influence the risk of significant liver fibrosis in patients with NAFLD.
非酒精性脂肪性肝病 (NAFLD) 患者的健康相关生活质量 (HRQoL) 受损，这往往与不健康的饮食模式有关。本研究旨在探讨 HRQoL 和对地中海饮食的依从性对 NAFLD 患者肝纤维化 (LF) 风险的影响。通过瞬时弹性成像 (FibroScan530. Echosens, Paris, France) 评估 244 例患者的 LF。根据肝硬度测量值 (LSM) 值≥7.1 kPa 定义显著 LF。还完成了地中海饮食评分和简短形式 36 问卷。中位年龄为 54（44-62）岁，57%的参与者为男性。共有 42 名（17.2%）参与者的 LSM≥7.1 kPa，与 LSM≤7.0 kPa 的参与者相比，GGT（ = 0.001）、血糖（ < 0.001）和甘油三酯水平（ = 0.015）升高。此外，LF 显著患者的生理机能（ < 0.001）和生理职能（ < 0.001）评分显著降低。在逻辑回归分析中，调整年龄、糖尿病和阻塞性睡眠呼吸暂停后，较低的生理职能和较低的地中海饮食依从性（ = 0.001 和 = 0.009）与显著 LF 的风险增加相关。地中海饮食依从性低和生理职能低可能会影响 NAFLD 患者发生显著肝纤维化的风险。
