Nadel S N, Greene A S, White R I, Anderson J H
Invest Radiol. 1986 Aug;21(8):631-6. doi: 10.1097/00004424-198608000-00006.
Recent advances in the diagnosis and treatment of cardiovascular pathology, including balloon angioplasty of atherosclerotic lesions in peripheral vascular disease, have led to an increased need for in vivo quantitation of blood flow. This study has three purposes: (1) to validate thermodilution techniques as a viable method for measuring low blood flow rates, (2) to calibrate accurately thermodilution catheters at these low flows, and (3) to develop an animal model that can be used to quantitate and compare many different flow measuring techniques. Modified commercially available 6F thermodilution catheters were used with a standard cardiac output computer to measure flows between 200 and 700 ml/minute. Eight anesthetized dogs were surgically interfaced with a variable flow, pressure, and compliance carotid-carotid/jugular bypass perfusion system. Three milliliters of normal saline at room temperature were injected through the catheters intra-arterially to measure different flows below, at, and above physiologic pressures and compliances. Results of this study indicate that with proper calibration, thermodilution techniques of measuring arterial and venous flows between 200 and 700 ml/minute are simple, accurate, and reliable. Using the designed system to generate known flows in vivo at various physiologic conditions allowed easy calibration of catheters and should facilitate calibration and comparison of other measurement techniques.
心血管疾病诊断与治疗方面的最新进展，包括外周血管疾病中动脉粥样硬化病变的球囊血管成形术，使得对体内血流量定量的需求增加。本研究有三个目的：（1）验证热稀释技术作为测量低血流量率的可行方法；（2）在这些低流量下准确校准热稀释导管；（3）建立一种可用于定量和比较多种不同流量测量技术的动物模型。使用经过改良的市售6F热稀释导管与标准心输出量计算机，测量200至700毫升/分钟之间的流量。八只麻醉犬通过手术与一个可变流量、压力和顺应性的颈动脉-颈动脉/颈静脉旁路灌注系统相连。通过导管向动脉内注入3毫升室温生理盐水，以测量低于、处于和高于生理压力及顺应性时的不同流量。本研究结果表明，经过适当校准后，测量200至700毫升/分钟之间动脉和静脉流量的热稀释技术简单、准确且可靠。利用设计的系统在各种生理条件下在体内产生已知流量，便于对导管进行校准，并应有助于其他测量技术的校准和比较。
