Unidad de Endocrinología Pediátrica, Complejo Hospitalario Universitario Insular Materno Infantil, 35016 Las Palmas de Gran Canaria, Spain.
Asociación Canaria para la Investigación Pediátrica (ACIP Canarias), 35004 Las Palmas de Gran Canaria, Spain.
Nutrients. 2023 Jul 7;15(13):3067. doi: 10.3390/nu15133067.
The role of Vitamin D in the development of type 1 diabetes (T1D) is controversial. The Canary Islands have the highest incidence of childhood-onset T1D in Spain and one of the highest in Europe. We aimed to evaluate 25OHVitamin D concentrations in a Canarian pediatric population, to assess the existence of seasonal variation, to study their association with T1D, and to evaluate the role of acidosis in its levels. In a retrospective, case-control study, we obtained data from 146 T1D patients (<15 years of age) and 346 control children; 25OHVitamin D concentrations were assessed in serum by automatic ChemiLuminescence ImmunoAssay technology. We found significantly higher 25OHVitamin D levels in the summer and autumn months and an inverse correlation between T1D and age; 25OHVitamin D sufficiency was similar in both groups (44.5% vs. 45.1%), with significant differences in the percentage of patients presenting vitamin D deficiency (11.6% (T1D) vs. 16.4% (controls)). When stratified according to the presence of ketoacidosis at sampling, only patients with acidosis showed lower 25OHVitamin D concentrations than controls. Despite its subtropical geographic location, Vitamin D deficiency is frequent in children in Gran Canaria, and 25OHVitamin D concentrations show seasonal variation. After adjusting for acidosis, no differences were found between children with and without T1D.
维生素 D 在 1 型糖尿病（T1D）发展中的作用存在争议。加那利群岛是西班牙儿童期发病 T1D 发病率最高的地区之一，也是欧洲发病率最高的地区之一。我们旨在评估加那利群岛儿科人群的 25OHVitamin D 浓度，评估其是否存在季节性变化，研究其与 T1D 的关系，并评估酸中毒对其水平的影响。在一项回顾性病例对照研究中，我们从 146 名 T1D 患者（<15 岁）和 346 名对照儿童中获得数据；通过自动化学发光免疫测定技术检测血清中的 25OHVitamin D 浓度。我们发现夏季和秋季的 25OHVitamin D 水平显著较高，并且 T1D 与年龄呈负相关；两组的 25OHVitamin D 充足率相似（44.5%对 45.1%），但维生素 D 缺乏症患者的比例存在显著差异（11.6%（T1D）对 16.4%（对照组））。根据采样时是否存在酮症酸中毒进行分层后，只有酸中毒患者的 25OHVitamin D 浓度低于对照组。尽管地理位置属于亚热带，但加那利群岛的儿童中维生素 D 缺乏症很常见，25OHVitamin D 浓度存在季节性变化。在调整酸中毒后，发现有 T1D 和无 T1D 的儿童之间没有差异。
