Ye Feihua, Chen Zhisheng, Li Chunsheng, Chen Junhua, Yi Guobin
School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, China.
Guangdong Provincial Key Laboratory of Environmental Health and Land Resource, Zhaoqing University, Zhaoqing 526061, China.
Polymers (Basel). 2023 Jun 29;15(13):2881. doi: 10.3390/polym15132881.
A phosphorylcholine polymer (poly(MPC-co-BMA-co-TSMA), PMBT) was prepared by free radical polymerization and coated on the surface of the polymethylpentene hollow fiber membrane (PMP-HFM). ATR-FTIR and SEM analyses showed that the PMBT polymer containing phosphorylcholine groups was uniformly coated on the surface of the PMP-HFM. Thermogravimetric analysis showed that the PMBT had the best stability when the molar percentage of MPC monomer in the polymer was 35%. The swelling test and static contact angle test indicated that the coating had excellent hydrophilic properties. The fluorescence test results showed that the coating could resist dissolution with 90% (%) ethanol solution and 1% (%) SDS solution. The PMBT coating was shown to be able to decrease platelet adherence to the surface of the hollow fiber membrane, and lower the risk of blood clotting; it had good blood compatibility in tests of whole blood contact and platelet adhesion. These results show that the PMBT polymer may be coated on the surface of the PMP-HFM, and is helpful for improving the blood compatibility of membrane oxygenation.
通过自由基聚合制备了一种磷酰胆碱聚合物（聚（MPC - co - BMA - co - TSMA），PMBT），并将其涂覆在聚甲基戊烯中空纤维膜（PMP - HFM）表面。衰减全反射傅里叶变换红外光谱（ATR - FTIR）和扫描电子显微镜（SEM）分析表明，含有磷酰胆碱基团的PMBT聚合物均匀地涂覆在PMP - HFM表面。热重分析表明，当聚合物中MPC单体的摩尔百分比为35%时，PMBT具有最佳稳定性。溶胀试验和静态接触角试验表明该涂层具有优异的亲水性。荧光测试结果表明该涂层能够抵抗90%（体积分数）乙醇溶液和1%（质量分数）十二烷基硫酸钠（SDS）溶液的溶解。结果表明，PMBT涂层能够减少血小板在中空纤维膜表面的黏附，并降低血液凝固的风险；在全血接触和血小板黏附试验中具有良好的血液相容性。这些结果表明，PMBT聚合物可涂覆在PMP - HFM表面，有助于改善膜氧合器的血液相容性。
