Bonagiri Pranay R, Shubrook Jay H
Touro University California, Vallejo, CA.
Clin Diabetes. 2020 Jul;38(3):256-265. doi: 10.2337/cd19-0077.
Debate is ongoing regarding the relationship between type 2 diabetes and cancer, and the pathways linking the two are incompletely understood. Some posit that the relationship hinges on a common predisposing factor such as obesity, insulin resistance, or chronic inflammation that increases the risk of cancer independently. Others speculate that diabetes acts as an independent risk factor for cancer because of other molecular pathways and interactions. Additionally, antidiabetic medications have been associated with changes in cancer risk. This review presents a summary of the latest studies and data concerning the relationships among type 2 diabetes, antidiabetic medications, cancer risk, and cancer prognosis.
关于2型糖尿病与癌症之间的关系，目前仍在进行讨论，而连接两者的途径尚未完全明确。一些人认为，这种关系取决于共同的易感因素，如肥胖、胰岛素抵抗或慢性炎症，这些因素会独立增加患癌风险。另一些人则推测，糖尿病由于其他分子途径和相互作用，而成为癌症的独立危险因素。此外，抗糖尿病药物与癌症风险的变化有关。本综述总结了关于2型糖尿病、抗糖尿病药物、癌症风险和癌症预后之间关系的最新研究和数据。
