Tran Edward, Nayeni Manav, Shah Nirmit, Malvankar-Mehta Monali S
Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada.
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
Eur J Ophthalmol. 2024 May;34(3):641-648. doi: 10.1177/11206721231185808. Epub 2023 Jul 14.
Age-related macular degeneration (AMD) is one of the leading causes of vision loss and blindness in older adults. Given the aging population in developed countries and the increased participation of older adults in the labour market, this paper aims to understand the impact of AMD on workplace productivity. Economic studies, comparative studies, observational studies, cohort studies, case series, randomized control trials, clinical trials, multicenter studies from MEDLINE, EMBASE, and CINHAL, as well as grey literature, were systematically searched to obtain all relevant literature. Duplicate records were removed, and two independent reviewers screened records for relevance. After screening, a risk of bias assessment was carried out. Data were extracted and a meta-analysis was performed using STATA 15.0. Fixed-effect and random-effect models were computed based on heterogeneity. Seven studies consisting of 3,060,864 subjects from 5 different countries were included in this systematic review. Mean wages lost due to impaired work productivity ranged from $1,395 to $55,180. The mean unemployment rate attributed to AMD ranged from 5.50% to 77.00%. Meta-analysis results indicated a significant unemployment rate (SMD = 0.44, CI: [0.27, 0.62]). Patients with AMD experience impaired work productivity as demonstrated by the wages lost and significantly higher rates of unemployment.
年龄相关性黄斑变性（AMD）是老年人视力丧失和失明的主要原因之一。鉴于发达国家人口老龄化以及老年人劳动力市场参与度的提高，本文旨在了解AMD对工作场所生产力的影响。系统检索了MEDLINE、EMBASE和CINHAL数据库中的经济研究、比较研究、观察性研究、队列研究、病例系列、随机对照试验、临床试验、多中心研究以及灰色文献，以获取所有相关文献。去除重复记录后，由两名独立评审员筛选记录的相关性。筛选后，进行了偏倚风险评估。提取数据并使用STATA 15.0进行荟萃分析。根据异质性计算固定效应模型和随机效应模型。本系统评价纳入了来自5个不同国家的7项研究，共3,060,864名受试者。因工作效率受损导致的平均工资损失在1,395美元至55,180美元之间。归因于AMD的平均失业率在5.50%至77.00%之间。荟萃分析结果显示存在显著的失业率（标准化均值差=0.44，置信区间：[0.27, 0.62]）。如工资损失和显著更高的失业率所示，AMD患者的工作效率受损。
