Kantar Health, Tel Aviv, Israel.
Novartis Pharmaceuticals, East Hanover, NJ 07936, USA.
J Comp Eff Res. 2018 Nov;7(11):1125-1132. doi: 10.2217/cer-2018-0058. Epub 2018 Sep 21.
To determine the economic and humanistic burden of neovascular age-related macular degeneration (nAMD) in a cohort of patients treated with anti-VEGF in Europe and the US.
PATIENTS & METHODS: 79 respondents from the EU and 63 from the US with a self-reported diagnosis of nAMD and in current receipt of treatment, as reported in an international, general population survey, were compared with non-nAMD controls.
Anti-VEGF-treated nAMD patients in the EU had a greater utilization of healthcare resources, poorer quality of life and greater overall activity impairment versus non-nAMD controls. In the US cohort, treated nAMD patients had significantly greater resource utilization for ophthalmologist visits only.
The burden of care associated with nAMD on EU and US healthcare systems, and on patients who are in receipt of nAMD therapy, is significant and likely to be unsustainable.
在接受抗血管内皮生长因子(anti-VEGF)治疗的欧洲和美国患者队列中,确定与年龄相关的新生血管性黄斑变性(nAMD)的经济和人文负担。
在一项国际一般人群调查中,报告了自我诊断为 nAMD 且正在接受治疗的 79 名欧盟和 63 名美国受访者,并与非 nAMD 对照组进行了比较。
与非 nAMD 对照组相比,接受抗 VEGF 治疗的 nAMD 患者在欧盟的医疗资源利用率更高、生活质量更差、整体活动能力受损更大。在美国队列中,仅接受治疗的 nAMD 患者眼科就诊的资源利用率显著更高。
nAMD 对欧盟和美国医疗体系以及接受 nAMD 治疗的患者带来的护理负担巨大,可能难以承受。