Wanifuchi Atsushi, Kyoda Yuki, Ogasawara Takuto, Kobayashi Ko, Ito Naoki, Shindo Tetsuya, Takahashi Atsushi, Kunishima Yasuharu, Masumori Naoya
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Department of Urology, NTT East Sapporo Hospital, Sapporo, Japan.
Curr Urol. 2023 Sep;17(3):174-178. doi: 10.1097/CU9.0000000000000197. Epub 2023 Apr 1.
We aimed to prospectively compare lower urinary tract symptoms in premenopausal and postmenopausal women with acute uncomplicated cystitis before and after antibiotic therapy.
This study included adult women with acute uncomplicated cystitis who visited 4 institutions between 2019 and 2020. After registration, we administered oral antibiotics and prospectively documented the changes in lower urinary tract symptoms from the first visit to a follow-up visit at 1 week using the Core Lower Urinary Tract Symptoms Score (CLSS) questionnaire.
After treatment, pyuria disappeared in 60 of the 66 patients (14 premenopausal and 46 postmenopausal). The CLSS total score (range) changed from 13 (3-29) to 4 (0-18) with a significant improvement in all CLSS items. At baseline, nocturia, urgency, and urgency incontinence were more prominent in postmenopausal women than in premenopausal women. In contrast, baseline urethral pain and quality of life index were more severe in premenopausal women than in postmenopausal women. After treatment, the CLSS total score was still higher in postmenopausal women, as reflected by the relatively higher scores for nocturia and urgency, irrespective of the comparable scores for urethral pain and the quality of life index in the 2 groups.
Our results suggest that if storage symptoms persist, they should be carefully interpreted according to menopausal status.
我们旨在前瞻性比较绝经前和绝经后患有急性单纯性膀胱炎的女性在抗生素治疗前后的下尿路症状。
本研究纳入了2019年至2020年间到4家机构就诊的患有急性单纯性膀胱炎的成年女性。登记后，我们给予口服抗生素，并使用核心下尿路症状评分（CLSS）问卷前瞻性记录从首次就诊到1周后随访时下尿路症状的变化。
治疗后，66例患者中的60例（14例绝经前和46例绝经后）脓尿消失。CLSS总分（范围）从13（3 - 29）变为4（0 - 18），所有CLSS项目均有显著改善。基线时，绝经后女性的夜尿、尿急和急迫性尿失禁比绝经前女性更突出。相比之下，绝经前女性的基线尿道疼痛和生活质量指数比绝经后女性更严重。治疗后，绝经后女性的CLSS总分仍然较高，夜尿和尿急得分相对较高就反映了这一点，尽管两组的尿道疼痛和生活质量指数得分相当。
我们的结果表明，如果储尿症状持续存在，应根据绝经状态仔细解读。
