Beebe-Dimmer Jennifer L, Finlay David G, Ruterbusch Julie J, Baird Tara, Simon Michael S, Abrams Judith, Harper Felicity W K, Podgorski Izabela, Heath Elisabeth I
Wayne State University, School of Medicine Departments of Oncology, Detroit, MI 48201, United States.
Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
Prev Med Rep. 2023 Jun 22;35:102288. doi: 10.1016/j.pmedr.2023.102288. eCollection 2023 Oct.
Given the well-documented benefits of regular exercise to cancer survivors, current American Cancer Society guidelines recommend that patients engage in a minimum of 150 min per week of moderate-to-vigorous physical activity with a minimum of two days of strength training. However, few survivors meet this goal, particularly among minorities.
The CAPABLE study is a single-arm, pilot exercise intervention that introduced 48 cancer survivors to a high intensity interval and strength training program three days a week for 12 weeks. We evaluated the impact of this unique training method on bodyweight, % body fat, serum markers correlated with an adverse cardiometabolic profile and health-related quality of life (HRQoL). Measures were summarized at baseline and program exit. Paired t-tests were used to assess change in each of these measures over time.
We observed losses in weight, body mass index, and % body fat, and glycosylated hemoglobin (HbA1c) levels over 12-weeks. There were also clinically meaningful improvements in reported overall HRQoL (FACTG total change +9.5 (95% CI, 4.6, 14.4)) and in each one of the individual domains (physical, social, emotional, and functional well-being).
We observed meaningful improvements in body composition, HbA1c and quality of life over 12 weeks among cancer survivors participating in a high-intensity interval training program. Future work will include a control arm for comparison and address barriers to participation and adherence which will be important in using this intervention and others like it to improve outcomes and reduce cancer health disparities.
鉴于定期锻炼对癌症幸存者有充分记录的益处，美国癌症协会目前的指南建议患者每周至少进行150分钟的中度至剧烈体育活动，且至少有两天进行力量训练。然而，很少有幸存者达到这一目标，尤其是少数族裔。
“有能力”（CAPABLE）研究是一项单组试点运动干预研究，该研究让48名癌症幸存者参加一项高强度间歇和力量训练计划，每周三天，为期12周。我们评估了这种独特训练方法对体重、体脂百分比、与不良心脏代谢状况相关的血清标志物以及健康相关生活质量（HRQoL）的影响。在基线和项目结束时对各项指标进行汇总。使用配对t检验来评估这些指标随时间的变化。
我们观察到在12周内体重、体重指数、体脂百分比和糖化血红蛋白（HbA1c）水平有所下降。报告的总体HRQoL（FACTG总分变化+9.5（95%CI，4.6，14.4））以及各个领域（身体、社会、情感和功能健康）均有临床意义的改善。
我们观察到参加高强度间歇训练计划的癌症幸存者在12周内身体成分、HbA1c和生活质量有显著改善。未来的工作将包括设置一个对照组进行比较，并解决参与和坚持训练的障碍，这对于使用这种干预措施及其他类似措施来改善结果和减少癌症健康差距至关重要。
