Tang Zhenchu, Lan Ziwei, Li Jing, Zhang Hedong, Gao Shan
Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Heliyon. 2023 Jun 29;9(7):e17785. doi: 10.1016/j.heliyon.2023.e17785. eCollection 2023 Jul.
To characterize the 100 most-cited articles in the field of Wilson's Disease (WD) to provide a general overview and reveal the historical developments classical studies, and new findings.
WD-related articles were searched on the Web of Science database. The 100 most-cited articles were retrieved and their descriptive statistics were analyzed.
The 100 most-cited articles in the field of WD were selected and several parameters, including citation count, citation density, first author, corresponding author, journal, country, institution, and keywords were extracted to assess the overall quality and impact of the articles.
Most of the selected 100 articles were published in the 1990s and 2000s, with the highest number of articles published in 2005. Citations per paper ranged from 100 to 1,631, with a mean number of citations of 199.03. The top 100 articles were published in 38 journals, and the majority were published in the . The most prominent research themes were clinical presentations, clinical trials, copper transport mechanisms, and dysregulation of copper metabolism. Prof. Svetlana Lutsenko, Prof. Peter Ferenci, Prof. George J. Brewer, and Prof. Diane W. Cox were among the most influential researchers in this field, while Euro-American countries were the most dominant in terms of research output. Keywords network analysis identified "Transporting ATPase," "," and "Menkes disease" as the most influential keywords. Moreover, disease management, WD clinical phenotype, function, and copper metabolism are potential hotspots in future WD research.
This study reveals the most influential articles in the field of WD research. In addition, the major research themes and technological innovations in the field of WD worldwide are presented.
对威尔逊病（WD）领域被引用次数最多的100篇文章进行特征分析，以提供总体概述，并揭示经典研究的历史发展和新发现。
在科学网数据库中搜索与WD相关的文章。检索出被引用次数最多的100篇文章，并对其描述性统计数据进行分析。
选取WD领域被引用次数最多的100篇文章，提取包括被引用次数、引用密度、第一作者、通讯作者、期刊、国家、机构和关键词等几个参数，以评估这些文章的整体质量和影响力。
所选的100篇文章大多发表于20世纪90年代和21世纪初，2005年发表的文章数量最多。每篇文章的被引用次数从100到1631不等，平均被引用次数为199.03。前100篇文章发表在38种期刊上，大多数发表在《 》上。最突出的研究主题是临床表现、临床试验、铜转运机制和铜代谢失调。斯韦特兰娜·卢岑科教授、彼得·费伦齐教授、乔治·J·布鲁尔教授和黛安·W·考克斯教授是该领域最有影响力的研究人员，而欧美国家在研究产出方面最为突出。关键词网络分析确定“转运ATP酶”“ ”和“门克斯病”为最具影响力的关键词。此外，疾病管理、WD临床表型、 功能和铜代谢是未来WD研究的潜在热点。
本研究揭示了WD研究领域最具影响力的文章。此外，还介绍了全球WD领域的主要研究主题和技术创新。
