Huang Weiheng, Jackstell Ralf, Franke Robert, Beller Matthias
Leibniz-Institut für Katalyse e. V., Albert-Einstein-Straße 29a, Rostock 18059, Germany.
Evonik Industries AG, Paul-Baumann-Strase. 1, 45772 Marl, Germany.
Chem Commun (Camb). 2023 Aug 1;59(62):9505-9508. doi: 10.1039/d3cc02277c.
Palladium-catalysed alkoxycarbonylation of alkenes allows for atom-efficient synthesis of esters from easily available alkenes in an industrially viable manner. One of the major costs associated with this process is the consumption of the catalyst system. Hence, for economic and ecologic reasons it is desirable to minimize the amount of metal and ligands wherever possible. Herein, we report "a homeopathic" palladium-catalysed alkoxycarbonylation of olefins under comparably mild conditions. The key to success is the homemade ligand LIKATphos providing good to excellent yields of ester products with catalyst turnover numbers in the range of 10.
钯催化的烯烃烷氧羰基化反应能够以工业上可行的方式，从容易获得的烯烃出发，实现原子经济性高效合成酯类。与该过程相关的主要成本之一是催化剂体系的消耗。因此，出于经济和生态原因，尽可能减少金属和配体的用量是很有必要的。在此，我们报道了在相对温和的条件下，“顺势疗法式的”钯催化烯烃烷氧羰基化反应。成功的关键在于自制的配体LIKATphos，它能提供良好至优异的酯产物收率，催化剂的周转数在10的范围内。
