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Unexpected role of complement component 8 gamma chain in the inflamed brain.

作者信息

Kim Jong-Heon, Suk Kyoungho

机构信息

Brain Science and Engineering Institute, Kyungpook National University, Daegu, Republic of Korea.

Brain Science and Engineering Institute, Kyungpook National University; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

出版信息

Neural Regen Res. 2023 Dec;18(12):2655-2656. doi: 10.4103/1673-5374.373706.

DOI:10.4103/1673-5374.373706
PMID:37449608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358680/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4a/10358680/8fbe68c886d4/NRR-18-2655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4a/10358680/8fbe68c886d4/NRR-18-2655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4a/10358680/8fbe68c886d4/NRR-18-2655-g001.jpg

相似文献

1
Unexpected role of complement component 8 gamma chain in the inflamed brain.补体成分8γ链在炎症大脑中的意外作用。
Neural Regen Res. 2023 Dec;18(12):2655-2656. doi: 10.4103/1673-5374.373706.
2
Complement levels in normal and inflamed aqueous humor.正常及炎性房水中的补体水平。
Invest Ophthalmol Vis Sci. 1983 Mar;24(3):380-4.
3
Complement Has Brains-Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?补体有大脑——细胞内补体和免疫代谢在组织稳态和行为中是否协同作用？
Front Immunol. 2021 Feb 25;12:629986. doi: 10.3389/fimmu.2021.629986. eCollection 2021.
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Complement factors in gingival crevice material from healthy and inflamed gingiva in humans.人类健康牙龈和炎症牙龈龈沟液中的补体因子。
J Periodontal Res. 1975 Feb;10(1):19-27. doi: 10.1111/j.1600-0765.1975.tb00003.x.
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Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.补体成分8γ对血脑屏障破坏的保护作用
Front Physiol. 2021 Jun 3;12:671250. doi: 10.3389/fphys.2021.671250. eCollection 2021.
6
Synthesis and regulation of the fourth component of complement (C4) in the human monocytic cell line U937: comparison with that of the third component of complement (C3).人单核细胞系U937中补体第四成分（C4）的合成与调节：与补体第三成分（C3）的比较
Immunology. 1992 Apr;75(4):565-9.
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Mannose-binding lectin as part of the complement pathway: characterization in non-inflamed and inflamed human eyes.甘露糖结合凝集素作为补体途径的一部分：在非炎症和炎症人眼中的特征。
Clin Exp Ophthalmol. 2011 Dec;39(9):871-7. doi: 10.1111/j.1442-9071.2011.02572.x. Epub 2011 Jun 29.
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Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.补体C5a受体（CD88）在炎症状态下的人类中枢神经系统中的反应性星形胶质细胞、小胶质细胞和内皮细胞上表达上调。
Am J Pathol. 1997 Jan;150(1):31-41.
9
Function of subunits within the eighth component of human complement: selective removal of the gamma chain reveals it has no direct role in cytolysis.人类补体第八成分内亚基的功能：γ链的选择性去除表明其在细胞溶解中无直接作用。
Biochemistry. 1984 Feb 28;23(5):832-7. doi: 10.1021/bi00300a008.
10
Interaction of the eighth component of guinea pig complement (C8) with the membrane-bound C5b-7 complex. The binding site of C8 to C5b-7 is formed on association of the alpha-gamma subunit with the beta-chain.豚鼠补体第八成分（C8）与膜结合的C5b-7复合物的相互作用。C8与C5b-7的结合位点在α-γ亚基与β链缔合时形成。
Microbiol Immunol. 1983;27(4):369-75. doi: 10.1111/j.1348-0421.1983.tb00595.x.

本文引用的文献

1
Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.补体成分8γ对血脑屏障破坏的保护作用
Front Physiol. 2021 Jun 3;12:671250. doi: 10.3389/fphys.2021.671250. eCollection 2021.
2
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.补体成分 8 的γ 亚基是一种神经炎症抑制剂。
Brain. 2021 Mar 3;144(2):528-552. doi: 10.1093/brain/awaa425.
3
Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease.补体在神经保护与神经炎症中的作用：从发育到疾病。
Trends Neurosci. 2021 Feb;44(2):97-109. doi: 10.1016/j.tins.2020.10.003. Epub 2020 Nov 12.
4
Complement in neurological disorders and emerging complement-targeted therapeutics.神经疾病中的补体及新兴的补体靶向疗法。
Nat Rev Neurol. 2020 Nov;16(11):601-617. doi: 10.1038/s41582-020-0400-0. Epub 2020 Oct 1.
5
Microglia mediate forgetting via complement-dependent synaptic elimination.小胶质细胞通过补体依赖性突触消除来介导遗忘。
Science. 2020 Feb 7;367(6478):688-694. doi: 10.1126/science.aaz2288.
6
Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review.阿尔茨海默病外周炎症生物标志物：简要综述。
BMB Rep. 2020 Jan;53(1):10-19. doi: 10.5483/BMBRep.2020.53.1.309.
7
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy.鞘氨醇 1-磷酸：病理与治疗中的脂质信号转导。
Science. 2019 Oct 18;366(6463). doi: 10.1126/science.aar5551.
8
Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.星形胶质细胞的血清类黏蛋白-2调节小胶质细胞激活和神经炎症。
J Neurosci. 2017 Mar 15;37(11):2878-2894. doi: 10.1523/JNEUROSCI.2534-16.2017. Epub 2017 Feb 13.
9
Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective.视黄醇结合蛋白-2作为脑损伤的治疗靶点：以星形胶质细胞为中心的视角
Prog Neurobiol. 2016 Sep;144:158-72. doi: 10.1016/j.pneurobio.2016.08.001. Epub 2016 Aug 4.
10
Unexpected and novel functions of complement proteins.补体蛋白的意外和新功能。
J Innate Immun. 2014;6(4):405-6. doi: 10.1159/000363198. Epub 2014 May 20.