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Restoration of GABA receptor expression in cerebral ischemia: a promising novel neuroprotective strategy.

作者信息

Bhat Musadiq A, Hleihil Mohammad, Benke Dietmar

机构信息

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

出版信息

Neural Regen Res. 2023 Dec;18(12):2659-2660. doi: 10.4103/1673-5374.373704.

DOI:10.4103/1673-5374.373704
PMID:37449610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358694/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7796/10358694/c45f97f5b939/NRR-18-2659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7796/10358694/c45f97f5b939/NRR-18-2659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7796/10358694/c45f97f5b939/NRR-18-2659-g001.jpg

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Front Pharmacol. 2025 Apr 28;16:1576884. doi: 10.3389/fphar.2025.1576884. eCollection 2025.
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本文引用的文献

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Protein phosphatase 2A regulation of GABA receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection.蛋白磷酸酶2A对γ-氨基丁酸受体的调节可使缺血诱导的异常受体转运正常化并提供神经保护作用。
Front Mol Neurosci. 2022 Oct 13;15:1015906. doi: 10.3389/fnmol.2022.1015906. eCollection 2022.
2
Targeting the interaction of GABA receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices.用干扰肽靶向 GABA 受体与 CaMKII 的相互作用可恢复脑缺血后的受体表达，并抑制小鼠脑细胞和脑片中的进行性神经元死亡。
Brain Pathol. 2023 Jan;33(1):e13099. doi: 10.1111/bpa.13099. Epub 2022 Jun 13.
3
Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies.
癫痫的发病机制、诊断与治疗：电磁刺激介导的神经调节疗法及新技术
Neural Regen Res. 2025 Apr 1;20(4):917-935. doi: 10.4103/NRR.NRR-D-23-01444. Epub 2024 Apr 3.
Targeting the Interaction of GABA Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death.
靶向缺血性损伤后GABA受体与CHOP的相互作用可恢复受体表达并抑制神经元进行性死亡。
Front Pharmacol. 2022 Mar 29;13:870861. doi: 10.3389/fphar.2022.870861. eCollection 2022.
4
Excitotoxicity: Still Hammering the Ischemic Brain in 2020.兴奋毒性：2020年仍在重创缺血性脑
Front Neurosci. 2020 Oct 26;14:579953. doi: 10.3389/fnins.2020.579953. eCollection 2020.
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Trends Mol Med. 2020 Jun;26(6):533-551. doi: 10.1016/j.molmed.2020.03.001. Epub 2020 Apr 4.
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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.尼替西农治疗急性缺血性脑卒中的疗效和安全性（ESCAPE-NA1）：一项多中心、双盲、随机对照试验。
Lancet. 2020 Mar 14;395(10227):878-887. doi: 10.1016/S0140-6736(20)30258-0. Epub 2020 Feb 20.
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Nanomedicine. 2019 Jun;18:380-390. doi: 10.1016/j.nano.2018.10.013. Epub 2018 Nov 11.
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Ca/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABA Triggers Lysosomal Degradation of GABA Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination.钙/钙调蛋白依赖性蛋白激酶 II（CaMKII）β依赖性 GABA 触发通过 Mind Bomb-2（MIB2）介导的 Lys-63 连接泛素化的 GABA 受体溶酶体降解的磷酸化。
Mol Neurobiol. 2019 Feb;56(2):1293-1309. doi: 10.1007/s12035-018-1142-5. Epub 2018 Jun 7.
9
Strategic approaches to optimizing peptide ADME properties.优化肽类药物吸收、分布、代谢和排泄特性的策略方法。
AAPS J. 2015 Jan;17(1):134-43. doi: 10.1208/s12248-014-9687-3. Epub 2014 Nov 4.
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Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface γ-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHOP).缺血样氧和葡萄糖剥夺通过内质网 (ER) 应激诱导的转录因子 CCAAT/增强子结合蛋白 (C/EBP)-同源蛋白 (CHOP) 介导细胞表面 γ-氨基丁酸 B 受体的下调。
J Biol Chem. 2014 May 2;289(18):12896-907. doi: 10.1074/jbc.M114.550517. Epub 2014 Mar 25.