• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

CD74: a prospective marker for reactive microglia?

作者信息

Potru Phani Sankar, Spittau Björn

机构信息

Anatomy and Cell Biology, Medical School OWL; Faculty of Biology, Bielefeld University, Bielefeld, Germany.

Faculty of Biology, Bielefeld University, Bielefeld, Germany.

出版信息

Neural Regen Res. 2023 Dec;18(12):2673-2674. doi: 10.4103/1673-5374.371350.

DOI:10.4103/1673-5374.371350
PMID:37449617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358643/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2680/10358643/423794805340/NRR-18-2673-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2680/10358643/423794805340/NRR-18-2673-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2680/10358643/423794805340/NRR-18-2673-g001.jpg

相似文献

1
CD74: a prospective marker for reactive microglia?CD74:反应性小胶质细胞的一种潜在标志物?
Neural Regen Res. 2023 Dec;18(12):2673-2674. doi: 10.4103/1673-5374.371350.
2
Microglial CD74 Expression Is Regulated by TGFβ Signaling.小胶质细胞 CD74 的表达受 TGFβ 信号通路调控。
Int J Mol Sci. 2022 Sep 6;23(18):10247. doi: 10.3390/ijms231810247.
3
MIF Receptor CD74 is Restricted to Microglia/Macrophages, Associated with a M1-Polarized Immune Milieu and Prolonged Patient Survival in Gliomas.巨噬细胞移动抑制因子受体CD74局限于小胶质细胞/巨噬细胞,与M1极化免疫环境相关,并可延长胶质瘤患者的生存期。
Brain Pathol. 2015 Jul;25(4):491-504. doi: 10.1111/bpa.12194. Epub 2014 Nov 20.
4
CD74 indicates microglial activation in experimental diabetic retinopathy and exogenous methylglyoxal mimics the response in normoglycemic retina.CD74表明实验性糖尿病视网膜病变中的小胶质细胞激活,外源性甲基乙二醛模拟正常血糖视网膜中的反应。
Acta Diabetol. 2014 Oct;51(5):813-21. doi: 10.1007/s00592-014-0616-9. Epub 2014 Jun 29.
5
CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia.短暂性脑缺血后,在沙鼠海马CA1区晚期可见CD74免疫反应性激活的M1小胶质细胞。
Mol Med Rep. 2017 Jun;15(6):4148-4154. doi: 10.3892/mmr.2017.6525. Epub 2017 Apr 28.
6
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice.一种独特类型的高度活化小胶质细胞通过Mif/Cd74信号轴在老年小鼠中引发脑部炎症。
Aging Dis. 2021 Dec 1;12(8):2125-2139. doi: 10.14336/AD.2021.0520. eCollection 2021 Dec.
7
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease.在阿尔茨海默病的神经原纤维缠结中,CD74 的表达增加。
Mol Neurodegener. 2008 Sep 11;3:13. doi: 10.1186/1750-1326-3-13.
8
MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis.MIF-CD74 信号通路抑制小胶质细胞 M1 极化并促进脑肿瘤发生。
Oncogene. 2016 Dec 1;35(48):6246-6261. doi: 10.1038/onc.2016.160. Epub 2016 May 9.
9
Up-Regulation of CD74 Expression in Parietal Epithelial Cells in a Mouse Model of Focal Segmental Glomerulosclerosis.局灶节段性肾小球硬化小鼠模型中壁层上皮细胞CD74表达上调
Nephron. 2016;134(4):238-252. doi: 10.1159/000448221. Epub 2016 Jul 28.
10
Added Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 Prevalence.抗 CD74 自身抗体在 HLA-B27 流行率低的人群中轴性脊柱关节炎的附加价值。
Front Immunol. 2019 Mar 26;10:574. doi: 10.3389/fimmu.2019.00574. eCollection 2019.

引用本文的文献

1
Microglia remodeling in the visual thalamus of the DBA/2J mouse model of glaucoma.青光眼DBA/2J小鼠模型视丘中小胶质细胞的重塑
PLoS One. 2025 May 15;20(5):e0323513. doi: 10.1371/journal.pone.0323513. eCollection 2025.
2
Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia.多模态单细胞分析揭示局灶性皮质发育异常中的神经元易损性和病理细胞状态。
iScience. 2024 Nov 6;27(12):111337. doi: 10.1016/j.isci.2024.111337. eCollection 2024 Dec 20.
3
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer's disease model.

本文引用的文献

1
Microglial CD74 Expression Is Regulated by TGFβ Signaling.小胶质细胞 CD74 的表达受 TGFβ 信号通路调控。
Int J Mol Sci. 2022 Sep 6;23(18):10247. doi: 10.3390/ijms231810247.
2
Profiling Microglia through Single-Cell RNA Sequencing over the Course of Development, Aging, and Disease.通过单细胞 RNA 测序在发育、衰老和疾病过程中对小胶质细胞进行分析。
Cells. 2022 Aug 2;11(15):2383. doi: 10.3390/cells11152383.
3
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice.一种独特类型的高度活化小胶质细胞通过Mif/Cd74信号轴在老年小鼠中引发脑部炎症。
在嵌合型阿尔茨海默病模型中,小胶质细胞耗竭可减轻人类神经元中与载脂蛋白E4(APOE4)相关的病理变化。
Cell Stem Cell. 2025 Jan 2;32(1):86-104.e7. doi: 10.1016/j.stem.2024.10.005. Epub 2024 Nov 4.
4
IMMUNE AND MOLECULAR CORRELATES OF RESPONSE TO IMMUNOTHERAPY REVEALED BY BRAIN-METASTATIC MELANOMA MODELS.脑转移黑色素瘤模型揭示的免疫治疗反应的免疫和分子关联
bioRxiv. 2024 Oct 9:2024.08.26.609785. doi: 10.1101/2024.08.26.609785.
5
Microglial Transforming Growth Factor-β Signaling in Alzheimer's Disease.小胶质细胞转化生长因子-β信号在阿尔茨海默病中的作用。
Int J Mol Sci. 2024 Mar 7;25(6):3090. doi: 10.3390/ijms25063090.
6
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.用于人类小胶质细胞的药理学工具包确定拓扑异构酶I抑制剂为阿尔茨海默病的免疫调节剂。
bioRxiv. 2024 Feb 6:2024.02.06.579103. doi: 10.1101/2024.02.06.579103.
Aging Dis. 2021 Dec 1;12(8):2125-2139. doi: 10.14336/AD.2021.0520. eCollection 2021 Dec.
4
Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair.MIF 细胞因子/CD74 受体通路在保护免受损伤和促进修复中的作用。
Front Immunol. 2020 Jun 23;11:1273. doi: 10.3389/fimmu.2020.01273. eCollection 2020.
5
Single-cell transcriptomic analysis of Alzheimer's disease.阿尔茨海默病的单细胞转录组分析。
Nature. 2019 Jun;570(7761):332-337. doi: 10.1038/s41586-019-1195-2. Epub 2019 May 1.
6
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.阿尔茨海默病的主要风险因素:年龄、性别和基因调节小胶质细胞对 Aβ 斑块的反应。
Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099.
7
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.单细胞分辨率下的小鼠和人类小胶质细胞的时空异质性。
Nature. 2019 Feb;566(7744):388-392. doi: 10.1038/s41586-019-0924-x. Epub 2019 Feb 13.
8
Silencing of TGFβ signalling in microglia results in impaired homeostasis.小胶质细胞中 TGFβ 信号的沉默导致内稳态受损。
Nat Commun. 2018 Oct 1;9(1):4011. doi: 10.1038/s41467-018-06224-y.
9
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.一种与限制阿尔茨海默病发展相关的独特小胶质细胞类型。
Cell. 2017 Jun 15;169(7):1276-1290.e17. doi: 10.1016/j.cell.2017.05.018. Epub 2017 Jun 8.
10
CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia.短暂性脑缺血后,在沙鼠海马CA1区晚期可见CD74免疫反应性激活的M1小胶质细胞。
Mol Med Rep. 2017 Jun;15(6):4148-4154. doi: 10.3892/mmr.2017.6525. Epub 2017 Apr 28.