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评估炎症状态与 COVID-19 严重程度的相关性:来自伊拉克三级医院的经验。

Assessment of the Correlation Between Inflammatory Status and Severity of COVID-19: Experience from Tertiary Hospital in Iraq.

机构信息

Department of Food Health and Nutrition, College of Food Sciences, Al-Qasim Green University, Al-Qasim, Babylon, Iraq.

University of Sheffield, Sheffield, UK.

出版信息

Curr Microbiol. 2023 Jul 14;80(9):283. doi: 10.1007/s00284-023-03407-9.

Abstract

As COVID-19 pandemic has strikingly hit the health systems of many countries, thus, the assessment of disease severity and its correlation with clinical and biochemical markers has become a necessity. These predictors can help in the diagnostics and therapeutics of COVID_19 and future viral respiratory tract infections. This was a cross-sectional study to assess the association between inflammatory makers and chronic conditions on computed tomography (CT) severity score, and D-dimer as a surrogate marker of disease severity. The results showed that inflammatory markers, age, were positively and significantly correlated with D-dimer, but inversely with oxygen saturation (SPO2). CT score showed similar pattern with exception of C-reactive protein. Vaccines had positive impact on CT severity score and Neutrophil to lymphocyte ration. These favorable outcomes provide us with affirmation regarding WHO and other international organizations that encourage people to take vaccines and especially patients, who suffer chronic diseases. The ramifications of the results are vast and pave the pathway to manage and assess COVID-19 patients in Iraq healthcare facilities.

摘要

随着 COVID-19 大流行对许多国家的卫生系统造成了巨大冲击,因此,评估疾病严重程度及其与临床和生化标志物的相关性已成为必要。这些预测因子可以帮助诊断和治疗 COVID-19 以及未来的病毒性呼吸道感染。这是一项横断面研究,旨在评估炎症标志物和慢性疾病与 CT 严重程度评分以及 D-二聚体作为疾病严重程度替代标志物之间的关联。结果表明,炎症标志物、年龄与 D-二聚体呈正相关且显著相关,但与血氧饱和度(SPO2)呈负相关。CT 评分与 C-反应蛋白相似,但有例外。疫苗对 CT 严重程度评分和中性粒细胞与淋巴细胞比率有积极影响。这些有利的结果为我们提供了世界卫生组织和其他国际组织的肯定,鼓励人们接种疫苗,特别是患有慢性病的患者。这些结果意义重大,为管理和评估伊拉克医疗机构的 COVID-19 患者铺平了道路。

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