Apple F S, Rogers M A
J Appl Physiol (1985). 1986 Aug;61(2):482-5. doi: 10.1152/jappl.1986.61.2.482.
In human gastrocnemius muscle obtained from long-distance runners, mitochondrial creatine kinase (CK) activities were significantly greater than nonrunning control skeletal muscle and significantly increased during training for and after a marathon race. Thus skeletal muscle tended to become similar to heart muscle in its mitochondrial CK composition. Total muscle CK activity was significantly different in males and females, was unaffected by marathon training and racing, and was similar to gastrocnemius muscle obtained from nonrunning controls. There was an inverse correlation between the maximum O2 uptake and the percentage increase in mitochondrial CK activity after training. These studies suggest that mitochondrial CK may play a key role in the intracellular transport of energy from mitochondrial to myofibrils in skeletal muscle during endurance exercise such as long-distance running.
在从长跑运动员身上获取的人类腓肠肌中，线粒体肌酸激酶（CK）的活性显著高于非跑步对照的骨骼肌，并且在马拉松比赛训练期间及之后显著增加。因此，骨骼肌在其线粒体CK组成上倾向于变得与心肌相似。肌肉总CK活性在男性和女性之间存在显著差异，不受马拉松训练和比赛的影响，并且与从非跑步对照中获取的腓肠肌相似。最大摄氧量与训练后线粒体CK活性的增加百分比之间存在负相关。这些研究表明，在诸如长跑等耐力运动期间，线粒体CK可能在骨骼肌中能量从线粒体向肌原纤维的细胞内转运中起关键作用。
