Clifford P S, Litzow J T, von Colditz J H, Coon R L
J Appl Physiol (1985). 1986 Aug;61(2):603-10. doi: 10.1152/jappl.1986.61.2.603.
To assess the role of intrapulmonary receptors on the ventilatory responses to exercise we studied six beagle dogs before and after chronic pulmonary denervation and five dogs before and after sham thoracotomies. Each exercise challenge consisted of 6 min of treadmill exercise with measurements taken during the third minute at 3.2 km/h, 0% grade, and during the third minute at 5.0 km/h, 0% grade. Inspiratory and expiratory airflows were monitored with a low-dead-space latex mask and pneumotachographs coupled to differential pressure transducers. Both pre- and postsurgery, all dogs exhibited a significant arterial hypocapnia and alkalosis during exercise. Denervation of the lungs had no significant effect on minute ventilation at rest or during exercise, although there was a lower frequency and higher tidal volume in the lung-denervated dogs at all measurement periods. Breathing frequency increased significantly during exercise in lung-denervated dogs but to a lesser magnitude than in the control dogs. The changes that occurred in breathing frequency in all animals were due predominantly to the shortening of expiratory time. Inspiratory time did not shorten significantly during exercise following lung denervation. We conclude from these data that intrapulmonary receptors which are deafferented by sectioning the vagi at the hilum are not responsible for setting the level of ventilation during rest or exercise but are involved in determining the pattern of breathing.
为了评估肺内感受器在运动通气反应中的作用，我们研究了6只比格犬在慢性肺去神经支配前后以及5只犬在假开胸手术前后的情况。每次运动挑战包括在跑步机上进行6分钟运动，在3.2公里/小时、坡度为0%的第三分钟以及5.0公里/小时、坡度为0%的第三分钟进行测量。吸气和呼气气流通过低死腔乳胶面罩和与压差传感器相连的呼吸流速计进行监测。手术前后，所有犬在运动期间均出现显著的动脉低碳酸血症和碱中毒。肺去神经支配对静息或运动时的分钟通气量没有显著影响，尽管在所有测量期间，肺去神经支配的犬的呼吸频率较低，潮气量较高。肺去神经支配的犬在运动期间呼吸频率显著增加，但增加幅度小于对照犬。所有动物呼吸频率的变化主要是由于呼气时间缩短。肺去神经支配后运动期间吸气时间没有显著缩短。从这些数据中我们得出结论，通过在肺门处切断迷走神经而失传入的肺内感受器不负责设定静息或运动时的通气水平，但参与确定呼吸模式。
