Chmielewski Piotr Paweł, Strzelec Bartłomiej, Data Krzysztof, Chmielowiec Krzysztof, Mozdziak Paul, Kempisty Bartosz
Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 6a Chalubinskiego Street, 50-368 Wrocław, Poland.
2nd Department of General Surgery and Surgical Oncology, Medical University Hospital, 50-556 Wroclaw, Poland.
J Clin Med. 2025 Jan 22;14(3):713. doi: 10.3390/jcm14030713.
Elevated body temperature is a well-established biomarker of infection, increased disease risk, and adverse health outcomes. However, the relationship between resting body temperature and long-term survival in older individuals is complex. Emerging evidence suggests that higher basal body temperature is associated with reduced survival and accelerated aging in non-obese older adults. This study aimed to compare body temperatures across different age groups in hospitalized older adults. Data were retrospectively collected from 367 physically healthy residents of a mental health center. Longitudinal data from 142 individuals (68 men and 74 women), aged 45 to 70 years and monitored continuously over 25 years, were compared with cross-sectional data from 225 individuals (113 men and 112 women) who underwent periodic clinical examinations with temperature measurements. The cross-sectional sample was stratified into four survival categories. Resting oral temperatures were measured under clinical conditions to ensure protocol consistency. Age-related changes in both sexes were evaluated using standard regression analysis, Student's -tests, ANOVA, and Generalized Linear Models. Longitudinal analysis revealed an increase in body temperature with age among women, while cross-sectional analysis showed that long-lived residents generally had lower body temperatures compared to their shorter-lived counterparts. These findings support the hypothesis that lower lifetime steady-state body temperature is associated with greater longevity in physically healthy older adults. However, further research is needed to determine whether the lower body temperature observed in long-lived individuals is linked to specific health advantages, such as enhanced immune function, absence of detrimental factors or diseases, or a reduced metabolic rate potentially influenced by caloric restriction.
体温升高是感染、疾病风险增加及不良健康后果的一项公认的生物标志物。然而，静息体温与老年人长期生存之间的关系较为复杂。新出现的证据表明，基础体温较高与非肥胖老年人的生存率降低和衰老加速有关。本研究旨在比较住院老年人不同年龄组的体温。数据回顾性收集自一家心理健康中心的367名身体健康的居民。将142名年龄在45至70岁之间且在25年期间持续监测的个体（68名男性和74名女性）的纵向数据，与225名接受定期临床检查并测量体温的个体（113名男性和112名女性）的横断面数据进行比较。横断面样本被分为四个生存类别。在临床条件下测量静息口腔温度以确保方案的一致性。使用标准回归分析、学生t检验、方差分析和广义线性模型评估两性与年龄相关的变化。纵向分析显示女性体温随年龄增加，而横断面分析表明，与寿命较短的居民相比，长寿居民的体温通常较低。这些发现支持了以下假设：在身体健康的老年人中，较低的终生稳态体温与更长的寿命相关。然而，需要进一步研究来确定在长寿个体中观察到的较低体温是否与特定的健康优势有关，例如增强的免疫功能、不存在有害因素或疾病，或可能受热量限制影响的代谢率降低。
