Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, 6 Clarendon Way, LS2 9JT Leeds, UK.
Leeds Institute for Data Analytics, University of Leeds, LS2 9JT Leeds, UK.
Eur Heart J Qual Care Clin Outcomes. 2023 Aug 7;9(5):442-446. doi: 10.1093/ehjqcco/qcad040.
The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) longitudinal cohort study aims to investigate health trajectories of individuals following hospitalization for myocardial infarction (MI).
EMMACE is a linked multicentre prospective cohort study of 14 899 patients with MI admitted to 77 hospitals in England who participated in the EMMACE-3 and -4 studies between 1st November 2011 and 24th June 2015. Long-term follow-up of the EMMACE cohorts was conducted through the EMMACE-XL (27th September 2020 to 31st March 2022) and EMMACE-XXL (1st July 2021 to 1st July 2023) studies. EMMACE collected individual participant data for health-related quality of life (HRQoL) measured by three-level EuroQol five-dimension and visual analogy scale at admission, 1 month, 6 months, 12 months, and 10 years follow-up, as well as medications, medication adherence, beliefs about medicines, Satisfaction with Information about Medicines Scale, and illness perceptions. Participant data were deterministically linked to the Myocardial Infarction National Audit Project (MINAP) for information on baseline treatments and comorbidities, Hospital Episode Statistics Admitted Patient Care (for cause-specific hospitalization data), and the Office for National Statistics (for mortality data) up to 2020.
EMMACE is a nationwide prospective cohort that will provide unique insights into fatal and non-fatal outcomes, medication adherence, and HRQoL following MI.Trial registration: ClinicalTrials.gov NCT01808027 and NCT01819103.
急性冠状动脉事件评估方法与管理（EMMACE）纵向队列研究旨在调查心肌梗死（MI）住院患者的健康轨迹。
EMMACE 是一项多中心前瞻性队列研究，纳入了 2011 年 11 月 1 日至 2015 年 6 月 24 日期间在英格兰 77 家医院接受 MI 治疗的 14899 例患者，随访时间通过 EMMACE-XL（2020 年 9 月 27 日至 2022 年 3 月 31 日）和 EMMACE-XXL（2021 年 7 月 1 日至 2023 年 7 月 1 日）研究进行。EMMACE 收集了患者入院时、1 个月、6 个月、12 个月和 10 年随访时的健康相关生活质量（HRQoL）的个体参与者数据，采用三级欧洲五维健康量表和视觉类比量表进行测量，以及药物治疗、药物依从性、对药物的信念、药物信息满意度量表和疾病认知。参与者数据通过确定性链接到心肌梗死国家审计项目（MINAP），以获取基线治疗和合并症信息、医院入院患者护理事件统计（特定疾病住院数据）和国家统计局（死亡率数据），截至 2020 年。
EMMACE 是一项全国性前瞻性队列研究，将为 MI 后的致命和非致命结局、药物依从性和 HRQoL 提供独特的见解。
ClinicalTrials.gov NCT01808027 和 NCT01819103。
