Javitt N B, Kok E, Carubbi F, Blizzard T, Gut M, Byon C Y
J Biol Chem. 1986 Sep 25;261(27):12486-9.
Metabolism of 3 beta-hydroxy-5-cholenoic acid to chenodeoxycholic acid has been found to occur in rabbits and humans, species that cannot 7 alpha-hydroxylate lithocholic acid. This novel pathway for chenodeoxycholic acid synthesis from 3 beta-hydroxy-5-cholenoic acid led to a reinvestigation of the pathway for chenodeoxycholic acid from 3 beta-hydroxy-5-cholenoic acid in the hamster. Simultaneous infusion of equimolar [1,2-3H]lithocholic acid and 3 beta-hydroxy-5-[14C]cholenoic acid indicated that the 14C enrichment of chenodeoxycholic acid was much greater than that of lithocholic acid. Thus, in all these species, a novel 7 alpha-hydroxylation pathway exists that prevents the deleterious biologic effects of 3 beta-hydroxy-5-cholenoic acid.
已发现，在无法对石胆酸进行7α-羟基化的兔和人类等物种中，3β-羟基-5-胆烯酸会代谢为鹅去氧胆酸。这条从3β-羟基-5-胆烯酸合成鹅去氧胆酸的新途径促使人们对仓鼠体内从3β-羟基-5-胆烯酸合成鹅去氧胆酸的途径进行重新研究。同时输注等摩尔的[1,2-³H]石胆酸和3β-羟基-5-[¹⁴C]胆烯酸表明，鹅去氧胆酸的¹⁴C富集度远高于石胆酸。因此，在所有这些物种中，都存在一条新的7α-羟基化途径，可防止3β-羟基-5-胆烯酸产生有害的生物学效应。
