Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford Eye Hospital,, West Wing LG1, Headley Way, Oxfordshire, OX3 9DU, England, UK.
Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
BMC Ophthalmol. 2023 Jul 14;23(1):322. doi: 10.1186/s12886-023-03038-5.
To describe a condition with the following features: chronic central serous chorioretinopathy (CCSC), chorioretinal folds, scleral changes (including any of the following flattened or 'squared off' posterior pole, 'T sign', or thickened ocular coats), accompanied by a short axial length and hypermetropia in a series of 7 patients.
The case notes of 7 patients presenting with a combination of CSC, choroidal folds scleral changes and hypermetropia were reviewed as part of a retrospective case series. Corrected visual acuities, serial refraction, colour imaging, fluorescein and indocyanine green angiography findings, together with B-ultrasound scan features were recorded, with axial length measurements as available (< 23.3 mm was defined as short).
The study included 14 eyes of 7 subjects (2 females and 5 males) with a primary presentation of central vision disturbance. All patients showed signs of previous or current episodes of the following features in at least one eye: CSC (5/7 bilateral); choroidal folds (6/7 bilateral), thickening of ocular coats in the 5 in whom this was measured, at least one scleral abnormality on ultrasound in at least one eye. A short axial length at final appointment was recorded in 13/14 eyes.
The combination of CCSC with choroidal folds, hypermetropia with apparent shortening of the eyeball associated with one or more scleral abnormalities such as a flattened or 'squared off 'appearance of the B ultrasound may be a specific ocular condition. The aetiology of this particular combination of posterior segment manifestations is unknown; the choroid could be the primary focus of disease with secondary involvement of the sclera. Alternatively, the features observed may result from a chronic inflammatory process affecting the sclera with secondary effects on the choroid, retinal pigment epithelium and retina. In our case series, the final vision was not significantly different from vision at presentation.
描述一种具有以下特征的疾病：慢性中心性浆液性脉络膜视网膜病变（CSC）、脉络膜视网膜皱褶、巩膜改变（包括以下任何一种：后极扁平或“方形”、“T 征”或眼外肌增厚），伴有一系列 7 例患者的短眼轴和远视。
回顾性病例系列研究中，对 7 例出现 CSC、脉络膜皱褶、巩膜改变和远视的患者的病历进行了回顾。记录了矫正视力、系列屈光度、彩色成像、荧光素和吲哚青绿血管造影结果以及 B 超扫描特征，同时记录了眼轴长度测量值（<23.3 毫米定义为短）。
该研究包括 7 名受试者（2 名女性和 5 名男性）的 14 只眼，主要表现为中心视力障碍。所有患者至少一眼出现以下一种或多种特征的既往或当前发作迹象：CSC（7 例双侧 5 例）；脉络膜皱褶（7 例双侧 6 例），在测量的 5 例中，至少一只眼的眼外肌增厚，至少一只眼的超声至少有一只眼的巩膜异常。13/14 只眼在最终就诊时记录了短眼轴。
CSC 伴脉络膜皱褶、远视伴眼球明显缩短，伴有一种或多种巩膜异常，如 B 超呈扁平或“方形”外观，可能是一种特定的眼部疾病。这种特定的后节表现组合的病因尚不清楚；脉络膜可能是疾病的主要焦点，其次是巩膜受累。或者，观察到的特征可能是由影响巩膜的慢性炎症过程引起的，对脉络膜、视网膜色素上皮和视网膜有继发影响。在我们的病例系列中，最终视力与就诊时视力无显著差异。
