Korkmaz Hilal, Hatipoğlu Mükerrem, Kayar Nezahat Arzu
Department of Periodontology, Faculty of Dentistry Akdeniz University, Antalya, Turkey.
Oral Dis. 2024 May;30(4):2523-2532. doi: 10.1111/odi.14657. Epub 2023 Jul 16.
The objective of this study was to compare the levels of gingival crevicular fluid (GCF), salivary, and serum matrix metalloproteinase-9, interleukin (IL)-17, IL-36γ, and IL-38 in individuals with healthy periodontium, gingivitis, and periodontitis and to evaluate their correlations with clinical periodontal parameters.
Ninety systemically healthy and nonsmoking volunteers divided into a healthy (H) group (n = 30), a gingivitis (G) group (n = 30), and a periodontitis (P) group (n = 30) were included in this study. Clinical periodontal parameters of volunteers were recorded, and GCF, unstimulated saliva, and serum samples were collected. Data analysis was done with enzyme-linked immunosorbent assays. The Kruskal-Wallis test and Bonferroni correction were used for multiple comparisons and post hoc statistical analyses.
The group H had significantly lower clinical parameters than the group P (p < 0.001). GCF and salivary IL-36γ and IL-38 levels were significantly higher in the group P than in the H and G groups (p < 0.05). Positive correlations between biochemical findings and clinical periodontal parameters were observed.
IL-36γ and IL-38 levels in GCF, saliva, and serum correlate with clinical periodontal parameters and may play a role in determining the activity of periodontitis.
本研究的目的是比较健康牙周组织、牙龈炎和牙周炎患者龈沟液（GCF）、唾液和血清中基质金属蛋白酶-9、白细胞介素（IL）-17、IL-36γ和IL-38的水平，并评估它们与临床牙周参数的相关性。
本研究纳入90名全身健康且不吸烟的志愿者，分为健康（H）组（n = 30）、牙龈炎（G）组（n = 30）和牙周炎（P）组（n = 30）。记录志愿者的临床牙周参数，并收集龈沟液、非刺激性唾液和血清样本。采用酶联免疫吸附测定法进行数据分析。采用Kruskal-Wallis检验和Bonferroni校正进行多重比较和事后统计分析。
H组的临床参数显著低于P组（p < 0.001）。P组龈沟液和唾液中IL-36γ和IL-38水平显著高于H组和G组（p < 0.05）。观察到生化指标与临床牙周参数之间存在正相关。
龈沟液、唾液和血清中的IL-36γ和IL-38水平与临床牙周参数相关，可能在确定牙周炎的活动中起作用。
