Wilson C A, Endersby C A
Neuroendocrinology. 1979;28(6):415-24. doi: 10.1159/000122890.
Immature rats can be induced to ovulate with pregnant mare serum (PMS) as long as they weigh over 60 g. In the rats weighing less than 60 g 5-hydroxytryptamine (5HT)-60 micrograms/rat intraventricularly or 2 micrograms/rat in the paraventricular nucleus (PVN)-stimulated ovulation. Injections into several other hypothalamic nuclei were ineffective. In rats weighing greater than 60 g, lesions of the PVN or injection of 10 micrograms/rat p-chlorophenylalanine into the PVN inhibited ovulation. The hypothalamic levels of 5HT and 5-hydroxy indole acetic acid (5HIAA) were generally lower in the afternoon and evening in the less than 60 g when compared with the greater than 60 g rats. It is possible that increased 5HT activity is required to stimulate ovulation and that its site of action is the PVN.
只要未成年大鼠体重超过60克，就可用孕马血清（PMS）诱导其排卵。体重小于60克的大鼠，脑室内注射5 - 羟色胺（5HT）60微克/只或在室旁核（PVN）注射2微克/只可刺激排卵。向其他几个下丘脑核团注射则无效。体重超过60克的大鼠，PVN损伤或向PVN注射10微克/只对氯苯丙氨酸可抑制排卵。与体重超过60克的大鼠相比，体重小于60克的大鼠下丘脑5HT和5 - 羟吲哚乙酸（5HIAA）水平通常在下午和晚上较低。可能需要增加5HT活性来刺激排卵，其作用部位是PVN。
