Lu Ling, Chen Bei, Zhang XinYi, Xu Yumeng, Jin Longtao, Qian Hui, Liang Zhao Feng
Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Front Pharmacol. 2023 Jun 29;14:1203265. doi: 10.3389/fphar.2023.1203265. eCollection 2023.
Gastric cancer is a common malignant tumor of the digestive tract, with a low early diagnosis rate. N-methyl-N-nitro-N-nitroguanidine (MNNG) is one of the main risk factors for gastric cancer. Phytochemicals are healthy active substances derived from vegetables, fruits, nuts, tea, herbal medicines and other plants. Taking phytochemicals is a very promising strategy for the prevention and treatment of gastric cancer. Many studies have proved that phytochemicals have protective effects on MNNG induced gastric cancer via inhibiting cell proliferation, enhancing immunity, suppressing cell invasion and migration, inducing apoptosis and autophagy, blocking angiogenesis, inhibiting infection as well as regulating metabolism and microbiota. The intervention and therapeutic effects of phytochemicals in MNNG induced gastric cancer have attracted more and more attention. In order to better study and explore the role, advantages and challenges of phytochemicals in MNNG induced gastric cancer, we summarized the intervention and therapeutic effects of phytochemicals in MNNG induced gastric cancer. This review may help to further promote the research and clinical application of phytochemicals in MNNG induced gastric cancer, and provide some new insights.
胃癌是常见的消化道恶性肿瘤，早期诊断率低。N-甲基-N-硝基-N-亚硝基胍（MNNG）是胃癌的主要危险因素之一。植物化学物质是源自蔬菜、水果、坚果、茶、草药及其他植物的健康活性物质。摄入植物化学物质是预防和治疗胃癌的一种非常有前景的策略。许多研究证明，植物化学物质通过抑制细胞增殖、增强免疫力、抑制细胞侵袭和迁移、诱导凋亡和自噬、阻断血管生成、抑制感染以及调节代谢和微生物群等对MNNG诱导的胃癌具有保护作用。植物化学物质对MNNG诱导的胃癌的干预和治疗作用已越来越受到关注。为了更好地研究和探索植物化学物质在MNNG诱导的胃癌中的作用、优势及挑战，我们总结了植物化学物质对MNNG诱导的胃癌的干预和治疗作用。本综述可能有助于进一步推动植物化学物质在MNNG诱导的胃癌中的研究及临床应用，并提供一些新的见解。
