Baek Sinhwa, Park Cho I, Hwang Yun Gyeong, Jeon Hyejin, Kim Seong-Eun, Song Aeri, Park Hyun-Je, Park Ilbum, Kang Jongsoo, Cha Joo Young
Yuhan Care Co., Ltd, Yuhan Care R&D Center, Yongin, 17084 Republic of Korea.
Yuhan Care Co., Ltd, Yuhan Natural Product R&D Center, Andong, 36618 Republic of Korea.
Food Sci Biotechnol. 2023 Feb 21;32(10):1435-1444. doi: 10.1007/s10068-023-01275-4. eCollection 2023 Sep.
Deer velvet (DV) is an oriental traditional medicine used to treat various diseases. The present study examined the effect of flavourzyme-derived DV extract (YC-1101) on macrophages and an immunosuppressed mouse model. YC-1101 induced activation of macrophages as measured by nitric oxide production, cell proliferation, and cytokine release via concentration-dependent phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, and AKT, and nuclear translocation of p65 in macrophages. In addition, oral YC-1101 administration significantly increased splenocyte proliferation and natural killer cell activity in the immunosuppressed mouse model. Moreover, the levels of immune-related cytokines such as tumor necrotic factor-α, interferon-γ, and interleukin-2 were significantly increased by YC-1101 treatment comparable to the control group. Thus, these results suggest that YC-1101 is an efficient natural ingredient that has an immune-enhancing effect, and it might be a potential functional food for improving immunity.
鹿茸是一种用于治疗各种疾病的东方传统药物。本研究检测了风味酶衍生的鹿茸提取物（YC - 1101）对巨噬细胞和免疫抑制小鼠模型的影响。通过一氧化氮产生、细胞增殖以及巨噬细胞中c - Jun氨基末端激酶、细胞外信号调节激酶和AKT的浓度依赖性磷酸化和p65的核转位所测量的细胞因子释放，YC - 1101诱导巨噬细胞活化。此外，在免疫抑制小鼠模型中，口服YC - 1101显著增加了脾细胞增殖和自然杀伤细胞活性。而且，与对照组相比，YC - 1101处理显著提高了肿瘤坏死因子 - α、干扰素 - γ和白细胞介素 - 2等免疫相关细胞因子的水平。因此，这些结果表明YC - 1101是一种具有免疫增强作用的有效天然成分，它可能是一种改善免疫力的潜在功能性食品。
