Garnier L, Mei N, Melone J
J Auton Nerv Syst. 1986 Jul;16(3):171-80. doi: 10.1016/0165-1838(86)90023-8.
The relationship between osmotic pressure in the intestinal lumen and gastric motor activity was studied in anesthetized cats. For this purpose the EMG was recorded in the antrum while the small intestine (duodenum and the first part of jejunum) was perfused with various solutions: tap water (5 mOsm), NaCl, mannitol and glucose having an osmotic pressure of 70, 138, 275, 550 or 1100 mOsm. Hypotonic and hypertonic solutions both induced a decrease in the gastric activity, i.e. an increase in period of electrical control activity. This effect was found to depend both on the osmolarity value (the osmotic pressures furthest removed from the isotonic value produced the greatest effect) and on the substance used (glucose, mannitol and NaCl, in decreasing order of efficiency). The isotonic solution of glucose and, to a lesser extent, of mannitol was also active, unlike the isotonic solution of NaCl. All these gastric changes were prevented by cervical bivagotomy. It was concluded that the vagal osmosensitive receptors located in the small intestine trigger this inhibitory enterogastric reflex which probably constitutes an important part in the regulation of gastric emptying.
在麻醉猫身上研究了肠腔内渗透压与胃运动活性之间的关系。为此，在向小肠（十二指肠和空肠第一段）灌注各种溶液（渗透压分别为5毫渗量的自来水、70、138、275、550或1100毫渗量的氯化钠、甘露醇和葡萄糖）时，记录胃窦的肌电图。低渗和高渗溶液均导致胃活动减少，即电控制活动期延长。发现这种效应既取决于渗透压值（与等渗值相差最远的渗透压产生的效应最大），也取决于所用物质（葡萄糖、甘露醇和氯化钠，按效率递减顺序排列）。葡萄糖等渗溶液以及程度稍轻的甘露醇等渗溶液也有活性，与氯化钠等渗溶液不同。所有这些胃部变化都可通过颈部双侧迷走神经切断术预防。得出的结论是，位于小肠的迷走渗透压感受器触发这种抑制性肠胃反射，这可能在胃排空调节中起重要作用。
