Staples R E, Goulding E H
Environ Health Perspect. 1979 Jun;30:105-13. doi: 10.1289/ehp.7930105.
Dipterex was teratogenic after administration by gavage (t.i.d.) at a dose level of 480 mg/kg-day to the CP rat on days 6 through 15 of gestation, but not when administered only on days 8 or 10 of gestation. A positive teratogenic response also occurred in the hamster after administration on days 7 through 11 of gestation at 400 mg/kg-day; the apparent no-effect level for the criteria studied was 200 mg/kg-day. Embryotoxicity, but not teratogenicity, occurred after administration of 400 mg/kg-day on day 8 of gestation. In both species, the teratogenicity seen was not merely due to reduced maternal food consumption during the period of exposure. The mouse was less susceptible to Dipterex than were the rat and hamster, but a significant increase in the incidence of cleft palates resulted from exposure on days 10 through 14, or on days 12 through 14 of gestation.
在妊娠第6至15天，以480毫克/千克·天的剂量水平对CP大鼠经口灌胃（每日三次）给予敌百虫后，敌百虫具有致畸性，但仅在妊娠第8天或第10天给药时则无致畸性。在妊娠第7至11天以400毫克/千克·天的剂量对仓鼠给药后，也出现了阳性致畸反应；所研究标准的明显无效应水平为200毫克/千克·天。在妊娠第8天以400毫克/千克·天的剂量给药后，出现了胚胎毒性，但无致畸性。在这两个物种中，所观察到的致畸性并非仅仅由于暴露期间母体食物摄入量减少所致。小鼠对敌百虫的敏感性低于大鼠和仓鼠，但在妊娠第10至14天或第12至14天暴露后，腭裂发生率显著增加。
