Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Department of Ultrasound, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 1;325(3):R280-R289. doi: 10.1152/ajpregu.00275.2022. Epub 2023 Jul 17.
Whether sex hormones are related to pain perception across the menstrual cycle is unclear. We examined changes in experimental pain perception in healthy young females between the early to midfollicular subphase (emF) and the midluteal subphase (mL) and explored the role of sex hormones. Sixty-six participants were involved in the study. We tested pressure pain, cold pain, ischemic pain, and needle pain, while at the same time we measured sex hormones levels in two menstrual subphases. Only the right ulna pressure test showed a significant reduction in pain threshold (PPTh3) during the mL. The absolute change of PPTh3 (PPTh3 - PPTh3) was related to the absolute change of prolactin. The relative change of the range of pain tolerance for pressure pain of the right ulna (RPT3) was related to the relative change of progesterone (P) and estradiol (E2) levels, and the interaction effects showed that at P ≤ 30, E2 was positively correlated with RPT3. The same, the relative change of pressure pain tolerance of the pulp of the middle finger on the right hand (PPTo4) was related to E2 and P, and the results of the interaction between E2 and P suggest that when E2 is ≤0.8, P is positively correlated with PPTo4. Two different formulas were applied in this study and showed inconsistent results. Most pain tests showed no difference between the two subphases of the menstrual cycle. Only the relative changes of the PPTo4 and RPT3 are related to the E2 and P, respectively, between menstrual subphases in an interactive way in healthy young women.
月经周期中性激素与疼痛感知的关系尚不清楚。我们在健康年轻女性中研究了卵泡早期至中期(subphase，emF)和黄体中期(subphase，mL)之间实验性疼痛感知的变化，并探讨了性激素的作用。共有 66 名参与者参与了研究。我们测试了压力痛、冷痛、缺血性疼痛和针刺痛，同时在两个月经亚相中测量了性激素水平。只有右尺骨压力测试显示在 mL 时疼痛阈值(PPTh3)显著降低。PPTh3 的绝对变化(PPTh3-PPTh3)与催乳素的绝对变化有关。右尺骨压力痛觉耐受范围的相对变化(RPT3)与孕激素(P)和雌二醇(E2)水平的相对变化有关，且交互作用表明，在 P ≤ 30 时，E2 与 RPT3 呈正相关。同样，右手中指末节压痛点痛觉耐受(RPT3)的相对变化与 E2 和 P 有关，E2 和 P 之间的交互作用结果表明，当 E2 ≤0.8 时，P 与 RPT3 呈正相关。本研究应用了两种不同的公式，结果不一致。大多数疼痛测试在月经周期的两个亚相中没有差异。只有在健康年轻女性中，PPTo4 和 RPT3 的相对变化分别与 E2 和 P 之间存在交互作用，与月经亚相相关。
