Zhang Luyao, Sun Mingyang, Ding Weiwei, Zhao Nan, Zhang Wei
Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Department of Ultrasound, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Int J Womens Health. 2025 Jun 12;17:1745-1754. doi: 10.2147/IJWH.S499942. eCollection 2025.
To explore the relationship between the level of endogenous sex hormones in the luteal phase and the pain threshold of healthy subjects, and to find the influencing factors of the change in female pain threshold.
Sixty-eight unmarried and nulliparous women, aged 22-28 years old, had regular menstruation with a cycle of 26-30 days, did not smoke, had no pain, no drug abuse, no gynecological problems, and had not participated in other clinical trials in the past 3 months. Blood was collected for analysis of sex hormone concentrations including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and four different pain thresholds were measured after abdominal ultrasound confirmed that the menstrual cycle was in the luteal phase.
During the luteal phase, a greater cold pain threshold was correlated with lower FSH (β=-0.743, =0.012). A greater ischemic pain threshold was correlated with higher LH concentrations (β=1.397, =0.011). A lower needle pain threshold was associated with higher FSH concentrations (β=0.32, =0.006), which could explain 19.8% of the total variance of pain from a needle used to draw blood pain threshold.
The needle pain threshold, cold pain threshold, ischemic pain threshold in the luteal phase of female healthy volunteers was, respectively, correlated with the concentrations of FSH or LH. These findings suggest that when formulating pain management strategies for women, the level of sex hormone concentrations should be considered, especially during the luteal phase, which may help provide more precise pain interventions for female patients and improve their pain experience.
探讨黄体期内源性性激素水平与健康受试者疼痛阈值之间的关系，并找出女性疼痛阈值变化的影响因素。
选取68名年龄在22 - 28岁之间、月经周期规律（26 - 30天）、不吸烟、无疼痛、无药物滥用、无妇科问题且在过去3个月内未参加过其他临床试验的未婚未育女性。采集血液分析性激素浓度，包括促卵泡生成素（FSH）、促黄体生成素（LH），在经腹部超声确认月经周期处于黄体期后测量四种不同的疼痛阈值。
在黄体期，冷痛阈值越高与FSH水平越低相关（β = -0.743，P = 0.012）。缺血性疼痛阈值越高与LH浓度越高相关（β = 1.397，P = 0.011）。较低的针刺疼痛阈值与较高的FSH浓度相关（β = 0.32，P = 0.006），这可以解释抽血用针疼痛阈值总方差的19.8%。
女性健康志愿者黄体期的针刺疼痛阈值、冷痛阈值、缺血性疼痛阈值分别与FSH或LH的浓度相关。这些发现表明，在为女性制定疼痛管理策略时，应考虑性激素浓度水平，尤其是在黄体期，这可能有助于为女性患者提供更精确的疼痛干预并改善她们的疼痛体验。
