Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea.
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea.
J Agric Food Chem. 2023 Jul 26;71(29):10916-10931. doi: 10.1021/acs.jafc.3c02156. Epub 2023 Jul 17.
As an alternative to petrochemical synthesis, well-established industrial microbes, such as , are employed to produce a wide range of chemicals, including dicarboxylic acids (DCAs), which have significant potential in diverse areas including biodegradable polymers. The demand for biodegradable polymers has been steadily rising, prompting the development of efficient production pathways on four- (C4) and five-carbon (C5) DCAs derived from central carbon metabolism to meet the increased demand via the biosynthesis. In this context, is utilized to produce these DCAs through various metabolic engineering strategies, including the design or selection of metabolic pathways, pathway optimization, and enhancement of catalytic activity. This review aims to highlight the recent advancements in metabolic engineering techniques for the production of C4 and C5 DCAs in .
作为石油化工合成的替代方法，已经建立的工业微生物，如 ，被用于生产各种化学品，包括二羧酸（DCAs），它们在包括可生物降解聚合物在内的多个领域具有重要潜力。对可生物降解聚合物的需求一直在稳步上升，这促使人们通过生物合成开发来自中心碳代谢的四（C4）和五（C5）二羧酸的高效生产途径，以满足不断增长的需求。在这种情况下，通过各种代谢工程策略，包括代谢途径的设计或选择、途径优化和催化活性的增强，来利用 生产这些 DCAs。本综述旨在强调在 中生产 C4 和 C5 DCA 的代谢工程技术的最新进展。
