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药物基因组学在精准精神病学中的作用。

The role of pharmacogenomics in precision psychiatry.

机构信息

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, 09127, Italy.

Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, 09127,Italy.

出版信息

Pharmacogenomics. 2023 Jul;24(10):523-527. doi: 10.2217/pgs-2023-0112. Epub 2023 Jul 17.

Abstract

The field of psychiatry is facing an important paradigm shift in the provision of clinical care and mental health service organization toward personalization and integration of multimodal data science. This approach, termed precision psychiatry, aims at identifying subgroups of patients more prone to the development of a certain phenotype, such as symptoms or severe mental disorders (risk detection), and/or to guide treatment selection. Pharmacogenomics and computational psychiatry are two fundamental tools of precision psychiatry, which have seen increasing levels of integration in clinical settings. Here we present a brief overview of these two applications of precision psychiatry in clinical settings.

摘要

精神病学领域在提供临床护理和精神卫生服务组织方面正面临着向个性化和多模态数据科学整合的重要范式转变。这种方法被称为精准精神病学,旨在识别更易发展为某种表型(如症状或严重精神障碍)的患者亚组(风险检测),和/或指导治疗选择。药物基因组学和计算精神病学是精准精神病学的两个基本工具,它们在临床环境中的整合程度不断提高。在这里,我们简要介绍了这两种精准精神病学在临床环境中的应用。

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