Department of Orthopedic Surgery and Orthopedic Research Institute, Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
Nano Lett. 2023 Sep 27;23(18):8816-8826. doi: 10.1021/acs.nanolett.3c01502. Epub 2023 Jul 17.
Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the elderly population worldwide. It is characterized by a progressive decline in muscle mass, strength, and performance. To date, clinical treatments in sarcopenia are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs) represent a novel kind of DNA-based nanomaterial with superior antiapoptosis capacity in cells, tissues, organs, and systems. In our study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated both in vivo and in vitro. Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic myotube atrophy was also ameliorated through the inhibition of mitochondria-mediated cell apoptosis. Collectively, tFNAs treatment might serve as an alternative option to deal with sarcopenia in the near future.
肌肉减少症又称与年龄相关的肌肉萎缩症，影响着全球超过四分之一的老年人。其特征是肌肉质量、力量和功能的进行性下降。迄今为止，肌肉减少症的临床治疗仅限于康复干预和饮食补充。四面体型核酸（tFNAs）是一种新型的基于 DNA 的纳米材料，具有优异的细胞、组织、器官和系统抗细胞凋亡能力。在我们的研究中，分别在体内和体外评估了 tFNAs 治疗对肌肉减少症的治疗效果。肌肉生物物理特性的结果表明，老年小鼠模型的肌肉功能和耐力得到了显著改善，组织学检查也显示出肌肉纤维的有益形态变化。体外，DEX 诱导的肌肉减少症肌管萎缩也通过抑制线粒体介导的细胞凋亡得到改善。总的来说，tFNAs 治疗可能是一种治疗肌肉减少症的替代方法。
