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本文引用的文献

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Monte Carlo simulation of shielding designs for a cabinet form factor preclinical MV-energy photon FLASH radiotherapy system.用于柜式外形临床前兆伏能量光子FLASH放射治疗系统的屏蔽设计的蒙特卡罗模拟
Med Phys. 2023 May;50(5):3055-3065. doi: 10.1002/mp.16290. Epub 2023 Feb 27.
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Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review.超高剂量率(FLASH)放射治疗的物理学和生物学:专题综述。
Phys Med Biol. 2020 Dec 4;65(23):23TR03. doi: 10.1088/1361-6560/abaa28.
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Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy.理解高剂量、超高剂量率和空间分割放射治疗。
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A method to optimize the shield compact and lightweight combining the structure with components together by genetic algorithm and MCNP code.一种通过遗传算法和蒙特卡罗输运程序(MCNP)代码将结构与部件相结合来优化屏蔽体紧凑性和轻量化的方法。
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Structural Shielding Design and Evaluation for Megavoltage X- and Gamma-Ray Radiotherapy Facilities.兆伏级X射线和伽马射线放射治疗设施的结构屏蔽设计与评估
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Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice.超高剂量率 FLASH 照射增加了小鼠正常组织和肿瘤组织之间的差异反应。
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临床放射治疗防护室内临床前韧致辐射 X 射线 FLASH 放疗系统的屏蔽分析。

Shielding Analysis of a Preclinical Bremsstrahlung X-ray FLASH Radiotherapy System within a Clinical Radiation Therapy Vault.

机构信息

Radiation Protection Department, SLAC, MS 48, 2575 Sand Hill Road, Menlo Park, CA 94025.

Technology Innovation Department, SLAC, MS 48, 2575 Sand Hill Road, Menlo Park, CA 94025.

出版信息

Health Phys. 2023 Oct 1;125(4):281-288. doi: 10.1097/HP.0000000000001718. Epub 2023 Jul 12.

DOI:10.1097/HP.0000000000001718
PMID:37459481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10502918/
Abstract

A preclinical radiotherapy system producing FLASH dose rates with 12 MV bremsstrahlung x rays is being developed at Stanford University and SLAC National Accelerator Laboratory. Because of the high expected workload of 6,800 Gy w -1 at the isocenter, an efficient shielding methodology is needed to protect operators and the public while the preclinical system is operated in a radiation therapy vault designed for 6 MV x rays. In this study, an analysis is performed to assess the shielding of the local treatment head and radiation vault using the Monte Carlo code FLUKA and the empirical methodology given in the National Council on Radiation Protection and Measurements Report 151. Two different treatment head shielding designs were created to compare single-layer and multilayer shielding methodologies using high-Z and low-Z materials. The multilayered shielding methodology produced designs with a 17% reduction in neutron fluence leaking from the treatment head compared to the single layered design of the same size, resulting in a decreased effective dose to operators and the public. The conservative assumptions used in the empirical methods can lead to over-shielding when treatment heads use polyethylene or multilayered shielding. High-Z/Low-Z multilayered shielding optimized via Monte Carlo is shown to be effective in the case of treatment head shielding and provide more effective shielding design for external beam radiotherapy systems that use 12 MV bremsstrahlung photons. Modifications to empirical methods used in the assessment of MV radiotherapy systems may be warranted to capture the effects of polyethylene in treatment head shielding.

摘要

斯坦福大学和 SLAC 国家加速器实验室正在开发一种产生 FLASH 剂量率的临床前放射治疗系统,该系统使用 12 MV 韧致辐射 X 射线。由于在等中心处预计的工作量高达 6800Gy w-1,因此需要一种有效的屏蔽方法,以便在为 6MV X 射线设计的放射治疗室中操作临床前系统时保护操作人员和公众。在这项研究中,使用蒙特卡罗代码 FLUKA 和国家辐射防护与测量委员会报告 151 中给出的经验方法对局部治疗头和辐射室的屏蔽进行了分析。创建了两种不同的治疗头屏蔽设计,以比较使用高 Z 和低 Z 材料的单层和多层屏蔽方法。与相同尺寸的单层设计相比,多层屏蔽方法使从治疗头泄漏的中子通量减少了 17%,从而降低了操作人员和公众的有效剂量。在经验方法中使用的保守假设可能会导致在治疗头使用聚乙烯或多层屏蔽时过度屏蔽。通过蒙特卡罗优化的高 Z/低 Z 多层屏蔽在治疗头屏蔽的情况下显示出有效性,并为使用 12 MV 韧致辐射光子的外束放射治疗系统提供更有效的屏蔽设计。可能需要对评估 MV 放射治疗系统中使用的经验方法进行修改,以捕捉治疗头屏蔽中聚乙烯的影响。