University of Ljubljana, Faculty of Medicine, Korytkova ulica 2, SI-1000 Ljubljana, Slovenia.
Institute of Oncology Ljubljana, Zaloška cesta 2, SI-1000 Ljubljana, Slovenia; University of Ljubljana, Veterinary Faculty, Gerbičeva ulica 60, SI-1000 Ljubljana, Slovenia.
Bioelectrochemistry. 2023 Dec;154:108509. doi: 10.1016/j.bioelechem.2023.108509. Epub 2023 Jul 13.
Electrochemotherapy (ECT) is used for treatment of unresectable abdominal malignancies. This study aims to show that ECT of porcine portal vein anastomosis is safe and feasible in order to extend the indications for margin attenuation after resection of locally advanced pancreatic carcinoma. No marked differences were found between the control group and ECT treated groups. Electroporation thus caused irreversible damage to the vascular smooth muscle cells in tunica media that could bedue to the narrow irreversible electroporation zone that may occur near the electrodes, or due to vasa vasorum thrombosis in the tunica externa. Based on the absence of vascular complications, and similar histological changes in lienal veinanastomosis, we can conclude that ECT of portal vein anastomosis is safe and feasible.
电化学疗法 (ECT) 用于治疗不可切除的腹部恶性肿瘤。本研究旨在表明，对猪门静脉吻合口进行 ECT 是安全可行的，以便扩大局部晚期胰腺癌切除后切缘衰减的适应证。在对照组和 ECT 治疗组之间未发现明显差异。电穿孔因此对中膜血管平滑肌细胞造成不可逆转的损伤，这可能是由于电极附近可能出现的狭窄不可逆转的电穿孔区，也可能是由于外膜中的血管腔隙血栓形成。基于没有血管并发症，以及肝静脉吻合口的类似组织学变化，我们可以得出结论，门静脉吻合口的 ECT 是安全可行的。
