Northeast Ohio Medical University, USA.
Northeast Ohio Medical University, USA.
Int J Pediatr Otorhinolaryngol. 2023 Aug;171:111659. doi: 10.1016/j.ijporl.2023.111659. Epub 2023 Jul 13.
Advancements in imaging and implantation technology have invited reexamination of the classic teaching that the human cochlea maintains uniform size across demographics. Yet, studies yield conflicting results and relatively few broad systematic reviews have examined cochlear size variation.
The purpose of this study is to quantify cochlear variability across eight different measurement categories and suggest normative values and ranges for each with consideration of disease state and gender where possible.
A systematic search was conducted up to October 1, 2022, using the search terms "Cochlea/anatomy and histology"[Mesh]) AND 'size'" with filters "Humans" and "English" across three databases (PubMed, CINAHL, Medline). Further inclusion criteria involved reporting of numerical measurements in any of the eight included categories.
Of the 625 articles manually reviewed for relevance by title and abstract, 91 were selected for full-text review and 33 met all eligibility criteria. 5,791 cochleae were included and weighted means and ranges were calculated: "A" value (defined as the distance from the round window, through the modiolus, to the oppsite lateral wall) = 9.23 mm (8.43-10.4 mm, n = 2559); cochlear duct length (CDL) = 33.04 mm (range 28.2-36.4 mm, n = 2252); cochlear height = 5.14 mm (2.8-6.9 mm, n = 2098); the basal turn lumen diameter = 2.09 mm (1.7-2.2 mm, n = 617); "B" value (defined as perpendicular to "A" value and in the same plane) = 6.52 mm (5.73-6.9 mm, n = 908); width of the basal turn = 6.4 mm (6.22-6.86 mm, n = 356); height of the basal turn = 1.96 mm (1.77-2.56 mm, n = 204); length of the basal turn 21.87 mm (21.03-22.5 mm, n = 384).
A notable size range exists across the eight different cochlear parameters considered and we provide normative values for each measurement. Females tend to have smaller CDL and "A" value than males and the sensorineural hearing loss patients had smaller CDL and "A" value but larger cochlear height than the general population.
成像和植入技术的进步促使人们重新审视经典理论，即人类耳蜗在不同人群中保持均匀的大小。然而，研究结果存在差异，且相对较少的广泛系统综述检查了耳蜗大小的变化。
本研究旨在量化八个不同测量类别中的耳蜗变异性，并提出每个类别的正常范围和范围，尽可能考虑疾病状态和性别。
使用搜索词“耳蜗/解剖学和组织学”[Mesh]和“大小”，并使用过滤器“人类”和“英语”，在三个数据库（PubMed、CINAHL 和 Medline）中进行了截至 2022 年 10 月 1 日的系统搜索。进一步的纳入标准包括在任何八个纳入类别中报告数值测量。
通过标题和摘要手动审查了 625 篇相关性文章，其中 91 篇进行了全文审查，33 篇符合所有纳入标准。共纳入 5791 个耳蜗，计算了加权平均值和范围：“A”值（定义为从圆窗到中轴，到相反的外侧壁的距离）=9.23 毫米（8.43-10.4 毫米，n=2559）；耳蜗管长度（CDL）=33.04 毫米（范围 28.2-36.4 毫米，n=2252）；耳蜗高度=5.14 毫米（2.8-6.9 毫米，n=2098）；基底回腔直径=2.09 毫米（1.7-2.2 毫米，n=617）；“B”值（定义为垂直于“A”值并在同一平面上）=6.52 毫米（5.73-6.9 毫米，n=908）；基底回宽度=6.4 毫米（6.22-6.86 毫米，n=356）；基底回高度=1.96 毫米（1.77-2.56 毫米，n=204）；基底回长度 21.87 毫米（21.03-22.5 毫米，n=384）。
在所考虑的八个不同耳蜗参数中存在显著的大小范围，我们为每个测量值提供了正常范围。女性的 CDL 和“A”值比男性小，感音神经性听力损失患者的 CDL 和“A”值比一般人群小，但耳蜗高度比一般人群大。
