Yamamoto K
Nihon Seikeigeka Gakkai Zasshi. 1986 Jun;60(6):663-70.
The depletion of proteoglycans in cartilage matrix is the beginning of cartilage breakdown. Prostaglandins and related compounds might play an important role in inhibition of cartilage metabolism under arthritic conditions. Prostaglandin endoperoxides, intermediate metabolites of arachidonic acid, are more potent chemical mediators than prostaglandins, but their action can only be demonstrated in cartilage co-incubated with synovial tissue, because they are short-lived and active only within a small restricted space. Human rheumatoid synovialis highly inhibited sulfation of cartilage matrix co-incubated. The inhibition of cartilage metabolism was released by indomethacin added to the co-incubating system, showing its responsiveness to indomethacin. The magnitude of inhibition was time-dependent and substantially greater than that by prostaglandin in cell-free rheumatoid synovial culture media. The results suggest a possible involvement of prostaglandin endoperoxides in potent inhibition of cartilage metabolism under arthritic conditions.
软骨基质中蛋白聚糖的耗竭是软骨破坏的开端。前列腺素及相关化合物可能在关节炎条件下抑制软骨代谢中发挥重要作用。前列腺素内过氧化物是花生四烯酸的中间代谢产物，比前列腺素具有更强的化学介质作用，但它们的作用只能在与滑膜组织共同孵育的软骨中得到证实，因为它们寿命短暂且仅在小范围内具有活性。人风湿性滑膜组织对共同孵育的软骨基质硫酸化有高度抑制作用。添加到共同孵育系统中的吲哚美辛可解除对软骨代谢的抑制，表明其对吲哚美辛有反应。抑制程度呈时间依赖性，且在无细胞的类风湿性滑膜培养基中比前列腺素引起的抑制作用大得多。结果表明，前列腺素内过氧化物可能参与了关节炎条件下对软骨代谢的强效抑制。
