非酒精性脂肪性肝病与血清尿酸与血清肌酐比值的相关性。
The correlation between NAFLD and serum uric acid to serum creatinine ratio.
机构信息
Department of Family Medicine, College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Department of Family Medicine, College of Medicine, Soonchunhyang University Cheonan Hospital, Chungnam, Republic of Korea.
出版信息
PLoS One. 2023 Jul 18;18(7):e0288666. doi: 10.1371/journal.pone.0288666. eCollection 2023.
BACKGROUND
With the prevalence of non-alcoholic fatty liver disease (NAFLD) increasing worldwide, many noninvasive techniques have been used to improve its diagnosis. Recently, the serum uric acid/creatinine (sUA/sCr) ratio was identified as an indicator of fatty liver disease. Therefore, we examined the relationship between sUA/sCr levels and ultrasound-diagnosed NAFLD in Korean adults.
METHODS
This study included 16,666 20-year-olds or older who received health checkups at a university hospital's health promotion center from January to December 2021. Among them, 11,791 non-patients with and without NAFLD were analyzed, excluding those without abdominal ultrasound, those without data on fatty liver, cancer, or chronic kidney disease severity, those with a history of alcohol abuse, and those with serum hs-CRP <5 mg/L. The odds ratio (OR) and 95% confidence interval (CI) of the sUA/sCr ratio according to the presence or absence of fatty liver disease and severity were calculated after correcting for confounding variables using logistic regression analysis. The receiver operating characteristic (ROC) curve and area under the curve (AUC) of the sUA/sCr ratio confirmed and compared the sensitivity and specificity of NAFLD and serum uric acid.
RESULTS
sUA/sCr increased with fatty liver severity, and the post-correction OR in the NAFLD group was 1.183 (95% CI: 1.137-1.231) compared to the group without NAFLD. Concerning the fatty liver severity, the post-correction OR in the mild NAFLD group increased to 1.147 (95% CI: 1.099-1.196), and that in the moderate-to-severe NAFLD group increased to 1.275 (95% CI: 1.212-1.341) compared to the group without NAFLD. The sensitivity of sUA/sCr to fatty liver severity was 57.9% for the non-NAFLD group, 56.7% for the mild NAFLD group, and 59.0% for the moderate-to-severe NAFLD group; the specificity of sUA/sCr to fatty liver severity 61.4% for the non-NAFLD group, 57.3% for the mild NAFLD group, and 65.2% for the moderate-to-severe NAFLD group.
CONCLUSION
NAFLD severity is associated with sUA/sCR.
背景
随着全球非酒精性脂肪性肝病（NAFLD）的患病率不断上升，许多非侵入性技术已被用于改善其诊断。最近，血清尿酸/肌酐（sUA/sCr）比值被确定为脂肪肝的一个指标。因此，我们研究了韩国成年人中 sUA/sCr 水平与超声诊断的 NAFLD 之间的关系。
方法
本研究纳入了 2021 年 1 月至 12 月在大学医院健康促进中心接受健康检查的 16666 名 20 岁及以上的成年人。其中，分析了 11791 名无 NAFLD 和有 NAFLD 的非患者，排除了无腹部超声、无脂肪肝数据、无癌症或慢性肾脏病严重程度数据、有酒精滥用史以及血清 hs-CRP<5mg/L 的患者。采用 logistic 回归分析校正混杂因素后，计算了 sUA/sCr 比值与脂肪肝和严重程度的比值比（OR）及其 95%置信区间（CI）。通过受试者工作特征（ROC）曲线和 sUA/sCr 比值的曲线下面积（AUC），比较了 NAFLD 和血清尿酸的敏感性和特异性。
结果
sUA/sCr 随脂肪肝严重程度而升高，与无 NAFLD 组相比，NAFLD 组校正后 OR 为 1.183（95%CI：1.137-1.231）。对于脂肪肝严重程度，轻度 NAFLD 组校正后 OR 增加至 1.147（95%CI：1.099-1.196），中度至重度 NAFLD 组增加至 1.275（95%CI：1.212-1.341）与无 NAFLD 组相比。sUA/sCr 对非 NAFLD 组脂肪肝严重程度的敏感性为 57.9%，对轻度 NAFLD 组为 56.7%，对中重度 NAFLD 组为 59.0%；sUA/sCr 对非 NAFLD 组脂肪肝严重程度的特异性为 61.4%，对轻度 NAFLD 组为 57.3%，对中重度 NAFLD 组为 65.2%。
结论
NAFLD 严重程度与 sUA/sCr 相关。
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