血清尿酸与高密度脂蛋白胆固醇比值与非酒精性脂肪肝的相关性：ABUND 研究。

The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study.

机构信息

Abant Izzet Baysal University Hospital, Department of Internal Medicine and Gastroenterology - Bolu, Turkey.

Abant Izzet Baysal University Hospital, Department of Internal Medicine - Bolu, Turkey.

出版信息

Rev Assoc Med Bras (1992). 2021 Apr;67(4):549-554. doi: 10.1590/1806-9282.20201005.

DOI:10.1590/1806-9282.20201005

PMID:34495059

Abstract

OBJECTIVE

Non-alcoholic fatty liver disease, which is characterized by lipid being deposited into hepatocytes, affects nearly one in three adults globally. Inflammatory markers were suggested to be related with hepatic steatosis. Uric acid to HDL cholesterol ratio is proposed as a novel inflammatory and metabolic marker. We aimed to compare Uric acid to HDL cholesterol ratio levels of patients with Non-alcoholic fatty liver disease to those of healthy controls and find out potential correlations between Uric acid to HDL cholesterol ratio and other inflammatory and metabolic markers of Non-alcoholic fatty liver disease.

METHODS

Patients with a diagnosis of Non-alcoholic fatty liver disease who were on clinical follow-up in our institution were enrolled in the study as the Non-alcoholic fatty liver disease group, while healthy volunteers were enrolled as the control group. The Uric acid to HDL cholesterol ratio of the groups was compared and potential correlations were studied between Uric acid to HDL cholesterol ratio and fasting blood glucose, transaminases, serum lipids (triglyceride, LDL-cholesterol), weight, and body mass index.

RESULTS

The Uric acid to HDL cholesterol ratio of the Non-alcoholic fatty liver disease (13±5%) group was significantly higher compared to the Uric acid to HDL cholesterol ratio of the control (10±4%) group (p<0.001). Uric acid to HDL cholesterol ratio was significantly and positively correlated with fasting blood glucose, transaminases, triglyceride, body weight, waist circumference, hip circumference, and body mass index. A ROC analysis revealed that a Uric acid to HDL cholesterol ratio level greater than 9.6% has 73% sensitivity and 51% specificity in determining Non-alcoholic fatty liver disease.

CONCLUSION

Due to the inexpensive and easy-to-assess nature of Uric acid to HDL cholesterol ratio, we suggest that elevated Uric acid to HDL cholesterol ratio levels be considered a useful tool in diagnosing hepatic steatosis.

摘要

目的

非酒精性脂肪性肝病（NAFLD）的特征是肝细胞内脂肪沉积，影响了全球近三分之一的成年人。炎症标志物被认为与肝脂肪变性有关。尿酸与高密度脂蛋白胆固醇（HDL-C）比值被认为是一种新的炎症和代谢标志物。我们旨在比较非酒精性脂肪性肝病患者和健康对照者的尿酸与 HDL-C 比值水平，并找出尿酸与 HDL-C 比值与非酒精性脂肪性肝病其他炎症和代谢标志物之间的潜在相关性。

方法

本研究纳入了在我院接受临床随访的非酒精性脂肪性肝病患者作为非酒精性脂肪性肝病组，健康志愿者作为对照组。比较了两组的尿酸与 HDL-C 比值，并研究了尿酸与 HDL-C 比值与空腹血糖、转氨酶、血脂（甘油三酯、LDL-C）、体重和体重指数之间的潜在相关性。

结果

非酒精性脂肪性肝病组（13±5%）的尿酸与 HDL-C 比值明显高于对照组（10±4%）（p<0.001）。尿酸与 HDL-C 比值与空腹血糖、转氨酶、甘油三酯、体重、腰围、臀围和体重指数呈显著正相关。ROC 分析显示，尿酸与 HDL-C 比值大于 9.6%时，诊断非酒精性脂肪性肝病的敏感性为 73%，特异性为 51%。