在振荡爆发和注意选择期间的路由状态转换。
Routing states transition during oscillatory bursts and attentional selection.
机构信息
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, USA.
出版信息
Neuron. 2023 Sep 20;111(18):2929-2944.e11. doi: 10.1016/j.neuron.2023.06.012. Epub 2023 Jul 17.
Brain-wide information routing relies on the spatio-temporal dynamics of neural activity, but it remains unclear how routing states emerge at fast spiking timescales and relate to slower activity dynamics during cognitive processes. Here, we show that localized spiking events participate in directional routing states with spiking activity in distant brain areas that dynamically switch or amplify states during oscillatory bursts, attentional selection, and decision-making. Modeling and neural recordings from lateral prefrontal cortex (LPFC), anterior cingulate cortex (ACC), and striatum of nonhuman primates revealed that cross-regional routing states arise within 20 ms following individual neuron spikes, with LPFC spikes leading the activity in ACC and striatum. The baseline routing state amplified during LPFC beta bursts between LPFC and striatum and switched direction during ACC theta/alpha bursts between ACC and LPFC. Selective attention amplified theta-/alpha-band-specific lead ensembles in ACC, while decision-making increased the lead of ACC and LPFC spikes to the striatum.
大脑范围内的信息路由依赖于神经活动的时空动力学，但目前尚不清楚路由状态如何在快速尖峰时间尺度上出现，并与认知过程中较慢的活动动力学相关。在这里，我们表明局部尖峰事件参与了具有远距离脑区尖峰活动的定向路由状态，这些状态在振荡爆发、注意力选择和决策过程中动态切换或放大状态。对非人类灵长类动物的外侧前额叶皮层 (LPFC)、前扣带皮层 (ACC) 和纹状体的建模和神经记录显示，跨区域路由状态在单个神经元尖峰后 20ms 内出现，LPFC 尖峰在前 ACC 和纹状体的活动之前。在 LPFC 和纹状体之间的 LPFC β爆发期间，基线路由状态放大，而在 ACC 和 LPFC 之间的 ACCθ/α爆发期间，路由状态切换方向。选择性注意放大了 ACC 中θ-/α 带特异性的先导集合，而决策增加了 ACC 和 LPFC 尖峰到纹状体的先导。
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