Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Vet Comp Oncol. 2023 Dec;21(4):587-594. doi: 10.1111/vco.12921. Epub 2023 Jul 19.
Renal carcinomas (RC) are uncommonly encountered in feline medicine. Limited information regarding clinical presentation and postoperative outcomes is available. The purpose of this multi-institutional, retrospective study was to describe the presenting features and clinical outcomes of cats with RC undergoing nephrectomy. Thirty-six client-owned cats were included. Medical records from participating institutions were searched to identify cats that had a histopathologic diagnosis of RC and underwent nephrectomy from January 2001 to October 2021. The most common presenting complaints were weight loss (36.1%) and hyporexia (30.6%). Based on preoperative imaging and intraoperative findings, eight cats had suspected metastasis at the time of surgery (22.2%). Twenty-eight cats survived to discharge (77.8%). Median progression free interval (PFI) could not be determined, as only six cats developed suspected recurrence (16.7%) and seven cats developed suspected metastasis (19.4%). The all-cause median survival time (MST) was 203 days (95% confidence interval [CI]: 84, 1379 days). When cases that died prior to discharge were excluded, MST increased to 1217 days (95% CI: 127, 1641 days). One-year, two-year, and three-year survival rates were all 40.4%. Neither renal tumour histologic subtype nor the presence of preoperative azotemia, anaemia, erythrocytosis, haematuria, or suspected metastasis at diagnosis were found to influence survival. For cats surviving to discharge, prolonged survival times were possible. Further studies are necessary to elucidate other potential prognostic factors, the utility of postoperative adjuvant treatment, and to identify cats at-risk of mortality in the perioperative period.
猫的肾脏肿瘤（RC）在兽医临床上较为少见。目前仅有少量关于其临床表现和术后转归的信息。本多中心回顾性研究的目的在于描述行肾切除术的 RC 患猫的临床表现和临床结局。共纳入 36 例患宠。检索参与机构的病历，以确定 2001 年 1 月至 2021 年 10 月期间经组织病理学诊断为 RC 且接受肾切除术的猫。最常见的就诊主诉为体重减轻（36.1%）和食欲减退（30.6%）。根据术前影像学和术中发现，8 例猫在手术时疑似发生转移（22.2%）。28 例猫存活至出院（77.8%）。无法确定无进展生存期（PFI），因为仅 6 例猫（16.7%）疑似复发，7 例猫（19.4%）疑似发生转移。所有原因的中位生存时间（MST）为 203 天（95%CI：84，1379 天）。当排除在出院前死亡的病例后，MST 增加至 1217 天（95%CI：127，1641 天）。1 年、2 年和 3 年的生存率均为 40.4%。肾脏肿瘤组织学亚型、术前是否存在氮质血症、贫血、红细胞增多症、血尿或诊断时疑似转移均与生存无关。对于存活至出院的猫，其生存时间可能延长。需要进一步的研究来阐明其他潜在的预后因素、术后辅助治疗的效用，并确定围手术期内死亡风险较高的猫。
