Kilburn K H
J Occup Med. 1986 Aug;28(8):714-8. doi: 10.1097/00043764-198608000-00034.
Strategies to prevent or reverse cancer promotion are described. One strategy, involving the screening and prompt treatment of small lung cancers, is proposed as a study to be tested in occupational groups with very high risk, specifically asbestos-exposed shipyard workers who smoke cigarettes. The relative risk can be assigned on the basis of (1) age, (2) years since first asbestos exposure, and (3) cigarette smoking amount, recency of cessation and age at onset. Proposed surveillance would be chest x-ray films at 4-month intervals and sputum cytology in current smokers and those within 10 years of cessation. Means of detection, such as monoclonal antibody tests for adenocarcinoma and other marker molecules, would be explored. Prompt conventional treatment would be assured. Other inquiries would be directed at new treatment, such as using targeted molecules directed at surface antigens.
文中描述了预防或逆转癌症进展的策略。其中一项策略是对小肺癌进行筛查和及时治疗，该策略拟作为一项研究，在高危职业人群中进行测试，特别是接触石棉且吸烟的造船厂工人。可根据以下因素确定相对风险：（1）年龄；（2）首次接触石棉后的年限；（3）吸烟量、戒烟时间和发病年龄。拟议的监测措施包括对现吸烟者和戒烟10年内的人每隔4个月进行胸部X光检查以及痰液细胞学检查。将探索检测手段，如针对腺癌和其他标志物分子的单克隆抗体检测。确保进行及时的传统治疗。其他研究将针对新的治疗方法，如使用针对表面抗原的靶向分子。
