Li Dong, Sun Wei, Chen Li, Gu Jing, Wu Huichun, Xu Huayu, Gan Jianhe
Department of Infection, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Suzhou, Jiangsu, China.
Open Life Sci. 2023 Jul 15;18(1):20220644. doi: 10.1515/biol-2022-0644. eCollection 2023.
This study explored the predictive value of the monocyte-to-lymphocyte ratio (MLR) and platelet-lymphocyte ratio (PLR) in patients with acute-on-chronic liver failure (ACLF). A retrospective analysis was carried out on 40 patients with ACLF from January 2018 and August 2019 in our hospital. The patient's clinical information during hospitalization was collected, and their survivals were followed for 3 months. MLR and PLR values of patients were compared, and the correlation between liver function indicators and prognosis was analyzed. We observed that MLR levels in the survival and death groups were 0.521 (0.311, 0.827) and 0.741 (0.442, 1.121), respectively. MLR levels were markedly enhanced in the death group compared to the survival group ( = 0.021). The receiver operating characteristic curve (ROC) exhibited that the area under the ROC curve and 95% confidence interval for the survival group was 0.641 (0.528-0.757). Survival analysis demonstrated that the 3-month survival of the high MLR group was markedly lower than that of the low MLR group ( = 0.001). Multivariate regression exposed that MLR and PLR were independent prognostic factors for ACLF. MLR and PLR could be prospective prognosticative markers of ACLF.
本研究探讨了单核细胞与淋巴细胞比值（MLR）和血小板与淋巴细胞比值（PLR）在慢性肝衰竭急性发作（ACLF）患者中的预测价值。对2018年1月至2019年8月我院收治的40例ACLF患者进行回顾性分析。收集患者住院期间的临床资料，并对其生存情况进行3个月的随访。比较患者的MLR和PLR值，并分析肝功能指标与预后的相关性。我们观察到，生存组和死亡组的MLR水平分别为0.521（0.311，0.827）和0.741（0.442，1.121）。与生存组相比，死亡组的MLR水平显著升高（P = 0.021）。受试者工作特征曲线（ROC）显示，生存组的ROC曲线下面积及95%置信区间为0.641（0.528 - 0.757）。生存分析表明，高MLR组的3个月生存率显著低于低MLR组（P = 0.001）。多因素回归分析显示，MLR和PLR是ACLF的独立预后因素。MLR和PLR可作为ACLF的前瞻性预后标志物。
