GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Laboratory, Guangzhou Medical University, Guangzhou, China.
Zhongshan School of Medicine, Sun Yat-Sen University, Guangdong, China.
Front Endocrinol (Lausanne). 2023 Jul 3;14:1215772. doi: 10.3389/fendo.2023.1215772. eCollection 2023.
Thermogenic fat, consisting of brown and beige adipocytes, dissipates energy in the form of heat, in contrast to the characteristics of white adipocytes that store energy. Increasing energy expenditure by activating brown adipocytes or inducing beige adipocytes is a potential therapeutic strategy for treating obesity and type 2 diabetes. Thus, a better understanding of the underlying mechanisms of thermogenesis provides novel therapeutic interventions for metabolic diseases. In this review, we summarize the recent advances in the molecular regulation of thermogenesis, focusing on transcription factors, epigenetic regulators, metabolites, and non-coding RNAs. We further discuss the intercellular and inter-organ crosstalk that regulate thermogenesis, considering the heterogeneity and complex tissue microenvironment of thermogenic fat.
棕色和米色脂肪细胞组成的产热脂肪以热量的形式消耗能量，与储存能量的白色脂肪细胞的特性形成对比。通过激活棕色脂肪细胞或诱导米色脂肪细胞来增加能量消耗是治疗肥胖症和 2 型糖尿病的一种潜在治疗策略。因此，更好地理解产热的潜在机制为代谢性疾病提供了新的治疗干预措施。在这篇综述中，我们总结了产热分子调控的最新进展，重点介绍了转录因子、表观遗传调节剂、代谢物和非编码 RNA。我们进一步讨论了调节产热的细胞间和器官间串扰，考虑到了产热脂肪的异质性和复杂的组织微环境。
