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Spexin 在基础和冷刺激条件下白色脂肪组织产热中的作用。

Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions.

机构信息

Neuroendocrinology Laboratory, Multidisciplinary Institute of Cellular Biology (IMBICE, CICPBA-CONICET-UNLP), La Plata 1900, Argentina.

Biology Department, School of Exact Sciences, La Plata National University, La Plata 1900, Argentina.

出版信息

Int J Mol Sci. 2024 Feb 1;25(3):1767. doi: 10.3390/ijms25031767.

DOI:10.3390/ijms25031767
PMID:38339044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10855774/
Abstract

Spexin (SPX) is a novel adipokine that plays an emerging role in metabolic diseases due to its involvement in carbohydrate homeostasis, weight loss, appetite control, and gastrointestinal movement, among others. In obese patients, SPX plasma levels are reduced. Little is known about the relationship between SPX and white adipose tissue (WAT) thermogenesis. Therefore, the aim of the present study was to evaluate the role of SPX in this process. C57BL/6J male mice were treated or not with SPX for ten days. On day 3, mice were randomly divided into two groups: one kept at room temperature and the other kept at cold temperature (4 °C). Caloric intake and body weight were recorded daily. At the end of the protocol, plasma, abdominal (epididymal), subcutaneous (inguinal), and brown AT (EAT, IAT, and BAT, respectively) depots were collected for measurements. We found that SPX treatment reduced Uncoupling protein 1 levels in WAT under both basal and cold conditions. SPX also reduced and mRNA levels and mitochondrial DNA, principally in IAT. SPX did not modulate the number of beige precursors. SPX decreased levels in IAT depots and in WAT depots. No differences were observed in the BAT depots. In conclusion, we showed, for the first time, that SPX treatment in vivo reduced the thermogenic process in subcutaneous and abdominal AT, being more evident under cold stimulation.

摘要

Spexin (SPX) 是一种新型的脂肪因子，由于其参与碳水化合物稳态、体重减轻、食欲控制和胃肠道运动等，在代谢性疾病中发挥着新兴作用。在肥胖患者中，SPX 血浆水平降低。关于 SPX 与白色脂肪组织 (WAT) 产热之间的关系知之甚少。因此，本研究旨在评估 SPX 在这一过程中的作用。C57BL/6J 雄性小鼠用或不用 SPX 处理十天。第 3 天，将小鼠随机分为两组：一组保持在室温下，另一组保持在冷环境（4°C）下。每天记录热量摄入和体重。在方案结束时，收集血浆、腹部（附睾）、皮下（腹股沟）和棕色脂肪组织（EAT、IAT 和 BAT）储存器以进行测量。我们发现 SPX 处理可降低基础和冷条件下 WAT 中的解偶联蛋白 1 水平。SPX 还降低了 和 mRNA 水平和线粒体 DNA，主要在 IAT 中。SPX 不调节米色前体的数量。SPX 降低了 IAT 储存器中的 水平和 WAT 储存器中的 水平。BAT 储存器中未观察到差异。总之，我们首次表明，SPX 体内治疗可减少皮下和腹部脂肪组织的产热过程，在冷刺激下更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/699e/10855774/145c9bd84de2/ijms-25-01767-g007.jpg
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