Dupuy Anne M, Cristol Jean P, Bargnoux Anne S, Plawecki Maelle, Lotierzo Manuela, Aguilar-Martinez Patricia, Badiou Stéphanie
Department of Biochemistry, Centre Ressources Biologiques de Montpellier University Hospital of Montpellier Montpellier France.
PhyMedExp University of Montpellier INSERM U1046, CNRS UMR 9214 Montpellier France.
Health Sci Rep. 2023 Jul 16;6(7):e1270. doi: 10.1002/hsr2.1270. eCollection 2023 Jul.
Mobility and migration flows are growing from different countries of the world to European countries, including France and in particular the Mediterranean basin. This study aimed to investigate the presence of hemoglobin (Hb) variants in outpatients/inpatients of the Montpellier Hospital (France) in whom an HbA1c assay had been performed and for which the country of birth had been informed.
This is a retrospective study from January 2016 to December 2020 based on all high-performance liquid chromatography (HPLC) chromatograms (Tosoh Bioscience HLC-723G8) having an alarm of suspected Hb variant during HbA1c measurement. The corresponding samples were systematically sent to the hematology laboratory for confirmation and identification of Hb variant. Patient's medical history, clinical and demographic data were extracted from each medical chart. Statistical analyses were performed using XLSTAT® software, version 2016.06.35661.
Three hundred sixty-three patients were confirmed with Hb variant exhibiting 17 different Hb profiles, highlighting the pivotal role of glycated hemoglobin (HbA1c) as a detection step. The prevalence of Hb variant in this southern French population was 0.71%, with the highest frequency for the beta-globin variants ( = 342/363; i.e., 94.2%), including the most common: S, C, E, and D in 200/342 (58.5%), 83/342 (24.3%), 29/342 (8.5%), and 11/342 (3.2%), respectively. Among patients with Hb variants, almost half (165/363; i.e., 45.4%) were born in the African continent with a predominance for Morocco (32/165; i.e., 19.3%) and Algeria (29/165; i.e., 17.5%).
HbA1c assay is a useful tool to detect Hb variants. Hemoglobinopathies are a public health issue in the current French population which is a multiethnic society. Despite the monocentric nature of our study, we note a high frequency of Hb variants in the south of France, which underlines the importance of screening for Hb variants in the whole population.
全球不同国家到欧洲国家，包括法国，尤其是地中海盆地的人口流动和迁移不断增加。本研究旨在调查蒙彼利埃医院（法国）门诊/住院患者中血红蛋白（Hb）变异体的存在情况，这些患者进行了糖化血红蛋白（HbA1c）检测且已告知出生国家。
这是一项回顾性研究，时间跨度为2016年1月至2020年12月，基于所有在HbA1c测量期间出现疑似Hb变异体警报的高效液相色谱（HPLC）色谱图（东曹生物科学HLC - 723G8）。相应样本被系统地送至血液学实验室以确认和鉴定Hb变异体。从每份病历中提取患者的病史、临床和人口统计学数据。使用XLSTAT®软件2016.06.35661版本进行统计分析。
363例患者被确诊存在Hb变异体，呈现出17种不同的Hb谱型，突出了糖化血红蛋白（HbA1c）作为检测步骤的关键作用。在法国南部人群中Hb变异体的患病率为0.71%，β - 珠蛋白变异体的频率最高（= 342/363；即94.2%），包括最常见的：S、C、E和D，分别为200/342（58.5%）、83/342（24.3%）、29/342（8.5%）和11/342（3.2%）。在有Hb变异体的患者中，近一半（165/363；即45.4%）出生于非洲大陆，其中摩洛哥（32/165；即19.3%）和阿尔及利亚（29/165；即17.5%）占比最大。
HbA1c检测是检测Hb变异体的有用工具。血红蛋白病在当前作为多民族社会的法国人群中是一个公共卫生问题。尽管我们的研究是单中心性质，但我们注意到法国南部Hb变异体的频率较高，这凸显了在整个人口中筛查Hb变异体的重要性。
