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华法林相关胎儿硬膜下血肿导致严重神经发育迟缓：一例报告

Warfarin-Associated Fetal Subdural Hematoma Causing Severe Neurodevelopmental Delay: A Case Report.

作者信息

Safra Ibrahim, Gad Ashraf, Alnaimi Shaikha Jabor

机构信息

Neonatal Intensive Care Unit, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Clinical Pharmacy Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

出版信息

Biomed Hub. 2023 Jul 5;8(1):54-59. doi: 10.1159/000531310. eCollection 2023 Jan-Dec.

DOI:10.1159/000531310
PMID:37465394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10350874/
Abstract

Fetal subdural hematoma is an antenatal finding associated with significant morbidity and mortality. It can occur due to maternal or fetal risk factors, and its management varies based on the underlying cause and the anticipated long-term outcomes. We present a case of warfarin-associated fetal subdural hematoma resulting in a live birth and severe neurodevelopmental delay by 10 years of age. In conclusion, counseling regarding the risk of fetal intracranial hemorrhage and the potential neurodevelopmental delay is essential in women who require anticoagulation with warfarin. In addition, close antenatal follow-up with fetal sonography and strict INR monitoring are essential preventative measures.

摘要

胎儿硬膜下血肿是一种与显著发病率和死亡率相关的产前发现。它可因母体或胎儿危险因素而发生，其管理因潜在病因和预期的长期结果而异。我们报告一例与华法林相关的胎儿硬膜下血肿病例，该病例导致活产，患儿10岁时出现严重神经发育迟缓。总之，对于需要使用华法林进行抗凝治疗的女性，就胎儿颅内出血风险和潜在神经发育迟缓进行咨询至关重要。此外，通过胎儿超声进行密切的产前随访和严格的国际标准化比值（INR）监测是重要的预防措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/649cd04ca28c/bmh-2023-0008-0001-531310_F06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/ac5ac8d6a713/bmh-2023-0008-0001-531310_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/0d30b40a7f97/bmh-2023-0008-0001-531310_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/6deeb8edc0d6/bmh-2023-0008-0001-531310_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/6e5ff1093a37/bmh-2023-0008-0001-531310_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/5ffbe262da35/bmh-2023-0008-0001-531310_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/649cd04ca28c/bmh-2023-0008-0001-531310_F06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/ac5ac8d6a713/bmh-2023-0008-0001-531310_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/0d30b40a7f97/bmh-2023-0008-0001-531310_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/6deeb8edc0d6/bmh-2023-0008-0001-531310_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/6e5ff1093a37/bmh-2023-0008-0001-531310_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/5ffbe262da35/bmh-2023-0008-0001-531310_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc5/10350874/649cd04ca28c/bmh-2023-0008-0001-531310_F06.jpg

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