Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Medical School of Chinese PLA, Beijing, China.
Front Immunol. 2023 Jul 3;14:1203070. doi: 10.3389/fimmu.2023.1203070. eCollection 2023.
Colon cancer is a complex disease that involves intricate interactions between cancer cells and theimmune microenvironment. MicroRNAs (miRNAs) have recently emerged as critical regulators of gene expression in cancer, including colon cancer. There is increasing evidence suggesting that miRNA dysregulation plays a crucial role in modulating the immune microenvironment of intestinal cancer. In particular, miRNAs regulate immune cell activation, differentiation, and function, as well as cytokine and chemokine production in intestinal cancer. It is urgent to fully investigate the potential role of intestinal cancer-related miRNAs in shaping the immune microenvironment.
Therefore, this paper aims to identify miRNAs that are potentially associated with colon cancer and regulate a large number of genes related to immune function. We explored the role of these genes in colon cancer patient prognosis, immune infiltration, and tumor purity based on data of 174 colon cancer patients though convolutional neural network, survival analysis and multiple analysis tools.
Our findings suggest that miRNA regulated genes play important roles in CD4 memory resting cells, macrophages.M2, and Mast cell activated cells, and they are concentrated in the cytokinecytokine receptor interaction pathway.
Our study enhances our understanding of the underlying mechanisms of intestinal cancer and provides new insights into the development of effective therapies. Additionally, identification of miRNA biomarkers could aid in diagnosis and prognosis, as well as guide personalized treatment strategies for patients with intestinal cancer.
结肠癌是一种复杂的疾病，涉及癌细胞与免疫微环境之间错综复杂的相互作用。微小 RNA（miRNA）最近被认为是癌症中基因表达的关键调节剂，包括结肠癌。越来越多的证据表明，miRNA 失调在调节肠道癌症的免疫微环境中起着至关重要的作用。特别是，miRNAs 调节免疫细胞的激活、分化和功能，以及肠道癌症中细胞因子和趋化因子的产生。充分研究与肠道癌症相关的 miRNAs 在塑造免疫微环境中的潜在作用迫在眉睫。
因此，本文旨在确定与结肠癌相关的潜在 miRNA，并调节与免疫功能相关的大量基因。我们通过卷积神经网络、生存分析和多种分析工具，基于 174 名结肠癌患者的数据，探讨了这些基因在结肠癌患者预后、免疫浸润和肿瘤纯度中的作用。
我们的研究结果表明，miRNA 调节的基因在 CD4 记忆静止细胞、巨噬细胞 M2 和 Mast 细胞激活细胞中发挥重要作用，它们集中在细胞因子-细胞因子受体相互作用途径中。
我们的研究增进了我们对肠道癌症潜在机制的理解，并为开发有效的治疗方法提供了新的思路。此外，鉴定 miRNA 生物标志物可能有助于诊断和预后，并指导肠道癌症患者的个性化治疗策略。
