草药混合物的植物治疗潜力及其对兔子中沙丁胺醇诱导的心脏毒性和高脂血症影响的研究。
Investigation of phytotherapeutic potential of herbal mixtures and their effects on salbutamol induced cardiotoxicity and hyperlipidemia in rabbits.
作者信息
Liaqat Nida, Jahan Nazish, Rahman Khalil Ur, Tahseen Iqra, Anwar Tauseef, Qureshi Huma
机构信息
Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan.
Department of Chemistry, Rawalpindi Women University, Rawalpindi, 46300, Pakistan.
出版信息
Bot Stud. 2023 Jul 19;64(1):23. doi: 10.1186/s40529-023-00394-9.
BACKGROUND
Cardiovascular diseases (CVDs) are the major cause of deaths all over the world. The high level of blood cholesterol and oxidative stress are major risk factors for heart diseases. The phytotherapeutics have attracted attention as potential agents for preventing and treating oxidative stress associated diseases. The objective of present study was to evaluate the synergetic cardio-protective and antilipidemic potential of medicinal plants viz. Coriandrum sativum, Piper nigrum and Cactus grandiflorus. Cardio-protective and anti-lipidemic potential of herbal mixture was evaluated against salbutamol induced cardiotoxicity in rabbits. For this purpose, rabbits were divided into six groups as normal control, salbutamol control, curative and standard drug curative.
RESULTS
Salbutamol significantly (p < 0.05) increased the level of serum cardiac biomarkers (ALT, CK-MB, AST and LDH) and lipids (LDL, triglycerides, cholesterol) in rabbits. The prior and post administration of herbal mixture significantly (p < 0.05) lowered the elevated level of serum cardiac biomarkers and lipids equal to normal control. Gross pathological examination revealed that heart of salbutamol control animals became hardened, congested and were enlarged than preventive and curative groups. The phytotherapeutic analysis of medicinal plants revealed the presence of phenols, tannins, alkaloids and steroids.
CONCLUSION
The results showed that this herbal mixture has strong cardio-protective and anti-lipidemic potential.
背景
心血管疾病（CVDs）是全球主要的死亡原因。高血胆固醇水平和氧化应激是心脏病的主要危险因素。植物疗法作为预防和治疗与氧化应激相关疾病的潜在药物已引起关注。本研究的目的是评估药用植物即芫荽、胡椒和大花仙人掌的协同心脏保护和抗血脂潜力。针对沙丁胺醇诱导的家兔心脏毒性，评估了草药混合物的心脏保护和抗血脂潜力。为此，将家兔分为六组，即正常对照组、沙丁胺醇对照组、治疗组和标准药物治疗组。
结果
沙丁胺醇显著（p < 0.05）提高了家兔血清心脏生物标志物（ALT、CK-MB、AST和LDH）和脂质（LDL、甘油三酯、胆固醇）水平。草药混合物给药前后显著（p < 0.05）降低了血清心脏生物标志物和脂质的升高水平，使其与正常对照组相当。大体病理检查显示，沙丁胺醇对照组动物的心脏比预防组和治疗组变硬、充血且增大。药用植物的植物疗法分析显示存在酚类、单宁、生物碱和类固醇。
结论
结果表明，这种草药混合物具有强大的心脏保护和抗血脂潜力。
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